Exploring the Cortical Hemodynamic Variability of Prefrontal iTBS: a Concurrent TBS/fNIRS Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Oxygenated hemoglobin (HbO) change compared to baseline
研究概览
简要总结
An increasing number of studies have used the intermittent theta-burst stimulation (iTBS) protocol to investigate neural plasticity non-invasively in the prefontal cortex in healthy humans and in patients with psychiatric disorders. However, the variability in the neurophysiological response to iTBS stimulation is high. The cause of this variability is multifactorial and to some degree still unknown. Therefore, the current study explores inter- and intra-individual factors that are potentially moderating iTBS-induced excitability changes. A greater understanding of these determinants would be highly valuable for optimizing the therapeutic application of iTBS.
详细描述
The investigators will measure the cortical excitability induced by iTBS with concurrent TBS/fNIRS technique in the same healthy individuals on multiple testing days. Meanwhile, several potential inter- (age, gender, etc.) and intra-individual factors (daily mood, daily physical activity levels, etc.) recently identified in non-invasive transcranial brain stimulation studies will be assessed before applying iTBS to the same individual on each testing day.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthiness based on history and psychiatric assessment
- •being able to hear and understand the verbal instructions
- •completed at least 6 years of formal education
排除标准
- •a current or past diagnosis of psychiatric, neurological disorders, or severe internal illness
- •any conditions that will contraindicate to iTBS or fNIRS
- •psychiatric disorders in their first-degree relatives
- •pregnancy
研究组 & 干预措施
Cortical hemodynamic variability of iTBS and its courses
A group of healthy adults shall undergo repeated experimental visits with concurrent TBS/fNIRS (3≤repetition≤15). An interval of at least two days (48 hours) between the visits is required to minimize carry-over effects from the iTBS protocols.
Inter- (age, gender, personality inventory, etc.) and intra-individual factors (daily mood, daily sleep quality, physical activity levels, etc.) that are potentially moderating iTBS-induced excitability changes will be explored.
干预措施: Intermittent theta burst stimulation (iTBS) (Device)
结局指标
主要结局
Oxygenated hemoglobin (HbO) change compared to baseline
时间窗: During and post TBS-fNIRS measurement, up to 3 months
iTBS-induced HbO change in the DLPFC before, during and after stimulation
次要结局
- Oxygen saturation change compared to baseline(During and post TBS-fNIRS measurement, up to 3 months)
- Deoxygenated hemoglobin (HbR) change compared to baseline(During and post TBS-fNIRS measurement, up to 3 months)
研究者
Dr Georg Kranz
Assistant Professor
The Hong Kong Polytechnic University