Detection Of Colonic Polyps In India: Diagnostic Colonoscopy

The third most common cancer in both male and female is colorectal carcinoma (CRC) worldwide. In India, it is the fourth most common cause of cancer in males and third most common cancer in females. The age - standardized rates of CRC in India have been estimated to be 4.2 and 3.2/100000 for males and females, respectively. Age, smoking and colonic adenoma along with family history is considered as traditional risk factors for CRC. The US National Polyp study demonstrated that colonoscopy and polypectomy could prevent 76% to 90% of colorectal cancers. The vast majority of CRC result from malignant transformation from adenomas. This is called adenoma - carcinoma sequence, these adenomatous polyps grows slowly over many years and malignant transformation eventually occurs. The time span for this transformation is on an average 10 years. So, the detection and removal of polyp at early stage on adenoma - carcinoma sequence should benefit in preventing CRC.

The prevalence of adenoma, utilization of colonoscopy for its detection and subsequent reduction in CRC has been well studied and established in western population. This has led to formulation of national screening colonoscopy programs elsewhere. However, data from Indian subcontinent is scanty. In current study, at a large tertiary care center, we aimed to study prevalence of colonic polyps and adenoma who are undergoing diagnostic colonoscopy using high definition colonoscopy and characterizing with Narrow Band Imaging and to find associated demographic, social, personal and family related risk factors in patients with adenomas.

Methodology:

This will be a prospective, single center, observational study. All subjects referred for diagnostic colonoscopy will be prospectively enrolled.

Enrollment: