NL-OMON34679已完成不适用
The effects of oral dipyridamole treatment on the innate immune response during human endotoxemia. - Effects of dipyridamole on innate immune response during human endotoxemia.
niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 30 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Age >= 18 and <= 35 years
排除标准
- •Use of any medication.
- •History of allergic reaction to dipyridamole
- •Bleeding disorder.
- •Previous spontaneous vagal collapse.
- •History, signs or symptoms of cardiovascular disease.
- •Cardiac conduction abnormalities on the ECG consisting of a 2nd degree atrioventricular block or a complex bundle branch block.
- •Hypertension (defined as RR systolic > 160 or RR diastolic > 90).
- •Hypotension (defined as RR systolic < 100 or RR diastolic < 50).
- •Renal impairment (defined as plasma creatinin >120 µmol/l).
- •Liver enzyme abnormalities or positive hepatitis serology.
- •Positive HIV serology or any other obvious disease associated with immune deficiency.
- •Febrile illness in the week before the LPS challenge.
- •Participation in a drug trial or donation of blood 3 months prior to the LPS challenge.
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