NCT01797601已完成不适用
Insulinsensitivität Des Menschlichen Zentralnervensystems: Kernspintomographische Untersuchung Mit Intranasaler Gabe Von Insulin
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Insulin effect on regional brain activity assessed by fMRI
研究概览
简要总结
The purpose of the study is to investigate whether insulin sensitivity and insulin resistance of the human brain is comparable in all insulin sensitive parts of the brain and whether correlates to other phenotypic information (i.e. whole body insulin sensitivity, BMI, age) of the study participants.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Normal routine blood works
- •for women: negative pregnancy test
排除标准
- •Type 2 diabetes
- •pregnancy
- •acute or chronic diseases
- •Pacemakers
- •Artificial heart valves
- •Metal prostheses
- •Implanted magnetic metal parts (screws, ...)
- •Metal fragments
- •insulin pumps
- •claustrophobia
- •reduced temperature sensation and / or increased sensitivity to warming of the body
- •Ear disease or an increased sensitivity to loud noises
研究组 & 干预措施
Human Insulin
Active Comparator
Nasal spray
干预措施: Human Insulin (Drug)
Placebo solution
Placebo Comparator
Nasal spray
干预措施: Placebo (Drug)
结局指标
主要结局
Insulin effect on regional brain activity assessed by fMRI
时间窗: Change from Baseline to 15 minutes and 60 minutes post spray application
次要结局
未报告次要终点
研究者
andreas fritsche
Prof. Andreas Fritsche
University Hospital Tuebingen
研究点 (1)
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