NCT05302752进行中（未招募）不适用
Quantification and Repeatability of Responses to Rapid Bilateral Magnetic Stimulation of the Phrenic Nerves
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- Diaphragm contractility
研究概览
简要总结
In this project the quantification and the repeatability of responses to rapid bilateral magnetic stimulation of the phrenic nerves will be investigated in healthy humans.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 39 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •non-smoking
- •normal lung function
- •body mass index: 18.5-29.9 kg/m2
- •able to communicate in english
- •willing to adhere to study rules
排除标准
- •acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep
- •intake of medications affecting metabolism, the cardiovascular, the neuromuscular or the respiratory system, or sleep
- •any metal or electronics inside of the body
- •presence of cardiac pacemaker, implanted defibrillators or implanted neurostimulators
- •history of seizures or epilepsy
- •tatoos on the stimulation sites
- •previous enrolment in this study
- •for women: pregnancy, breastfeeding, or intention to become pregnant during the study
研究组 & 干预措施
Bilateral rapid magnetic stimulation of the phrenic nerves
Experimental
Each participant will be tested on three different days with optimal settings for bilateral rapid magnetic stimulation of the phrenic nerves established on visit 1 and then repeated on visits 2 and 3.
干预措施: Magnetic phrenic nerve stimulation (Other)
结局指标
主要结局
Diaphragm contractility
时间窗: Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec
Transdiaphragmatic pressure changes, i.e. changes in esophageal and gastric pressures, will be measured by a pressure transducer connected to balloon-catheters.
次要结局
未报告次要终点
研究者
研究点 (2)
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