Characteristics of Ankylosing Spondylitis Associated Uveitis: A Retrospective Study in Egyptian Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Change in Corrected Distance Visual Acuity (CDVA)
研究概览
简要总结
This study aims to understand the clinical characteristics associated with AAU in Egyptian AS patients, and the prognostic factors, in terms of the Corrected Distance Visual Acuity (CDVA).
详细描述
This is a one-year retrospective cohort study conducted at the Spine and Ophthalmology Clinics of Benha University - Faculty of Medicine, Egypt, between September 2023 and August 2024. The study aims to characterize the clinical features and identify prognostic factors affecting visual outcomes in patients with Ankylosing Spondylitis-associated Anterior Uveitis (ASAAU).
Patients included in this study were Egyptian nationals who initially presented to the Spine Clinic with systemic symptoms of ankylosing spondylitis (AS) and were subsequently referred to the Ophthalmology Clinic due to ophthalmic complaints. Only patients who were confirmed to have both AS (diagnosed according to the Modified New York criteria and radiographic imaging) and anterior uveitis (confirmed by slit-lamp examination and supported by Optical Coherence Tomography [OCT] and Fluorescein Angiography [FA]) were enrolled.
The final sample included 26 eyes from 22 patients who fulfilled the inclusion criteria. Patients were excluded if they were non-Egyptian, had other systemic autoimmune or immunologic conditions, had uveitis due to secondary causes, had undergone ocular surgeries, did not receive uveitis treatment, were lost to follow-up, or had incomplete medical records.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Egyptian nationality.
- •Age: ≥ 18 years.
- •Confirmed diagnosis of Ankylosing Spondylitis (AS) according to the Modified New York Criteria, including:
- •Clinical symptoms (e.g., chronic inflammatory back pain, reduced lumbar motion, reduced chest expansion)
- •Radiographic evidence of sacroiliitis.
- •Confirmed diagnosis of Acute Anterior Uveitis (AAU) based on:
- •Ophthalmologic examination (e.g., slit-lamp biomicroscopy)
- •Ancillary testing (e.g., Optical Coherence Tomography [OCT] and/or Fluorescein Angiography [FA]).
- •Presentation to the Spine Clinic of Benha University - Faculty of Medicine between September 2023 and August 2024 with ophthalmic complaints, subsequently referred to the Ophthalmology Clinic.
- •Complete medical and ophthalmologic records available.
- •Received treatment for both AS and AAU.
- •At least one follow-up visit after initiation of treatment.
排除标准
- •Non-Egyptian patients.
- •History of other systemic autoimmune or immunological diseases (e.g., sarcoidosis, Behçet's disease, systemic lupus erythematosus).
- •Uveitis due to non-autoimmune secondary causes (e.g., infectious uveitis, trauma-related uveitis).
- •History of ocular surgery prior to the episode of AAU
结局指标
主要结局
Change in Corrected Distance Visual Acuity (CDVA)
时间窗: Baseline and 3-month follow-up
CDVA was assessed at baseline (initial presentation) and after treatment (follow-up average of 3 months), using the Logarithm of the Minimum Angle of Resolution (logMAR) scale. Improvement or deterioration in CDVA was evaluated in relation to clinical characteristics, treatment modalities, and complication development.
次要结局
未报告次要终点
研究者
Ehab Mohamed Elsayed Mohamed Saad
Lecturer
Benha University