NCT07658014已完成不适用
Initial Diastolic Shock Index and Lactate as Predictors of Occult Vasoplegia in Normotensive Sepsis.
Hospital H+ Queretaro1 个研究点 分布在 1 个国家目标入组 526 人开始时间: 2024年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 526
- 试验地点
- 1
研究概览
简要总结
The goal of this observational study is to learn if the Diastolic Shock Index (DSI) and initial lactate can predict occult vasoplegia in adults with normotensive sepsis. Normotensive sepsis occurs in patients who have an apparently normal mean arterial pressure but may have impaired vascular tone.
The main questions it aims to answer are:
- Can an elevated DSI at admission predict the initiation of vasopressors (norepinephrine) within the first 6 hours of intensive care unit stay?
- How does the combination of initial DSI and lactate perform compared to each marker alone in predicting hemodynamic deterioration? Researchers will compare patients with an elevated DSI to those with a normal DSI to see if this index identifies those who will progress to circulatory shock.Since this is a retrospective cohort study using existing medical records, participants will not be asked to perform any tasks. Researchers will analyze anonymized data, such as heart rate, blood pressure, and lactate levels already recorded in the institutional database.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients over 18 years of age.
- •Diagnosis of sepsis upon admission according to Sepsis-3 criteria (suspected or confirmed infection plus an increase in SOFA score >2).
- •Mean Arterial Pressure (MAP) during the first hour >=65 mmHg.
- •No vasopressor infusion at the time of initial assessment (Time 0)
排除标准
- •Patients who died within the first 24 hours of admission.
- •Patients transferred out of the unit within the first 24 hours
- •Patients who were already receiving vasopressor support in the pre-hospital setting or the emergency department before ICU admission.
研究者
Jose J Zaragoza, MD MSc
Amy Sevilla
Hospital H+ Queretaro
研究点 (1)
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