An Observational Study on outcomes of hyperlactatemia on admission in critically ill patients.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Development of multi organ dysfunction syndrome(MODS)
研究概览
简要总结
Elevated lactate levels serve as a biomarker for tissue hypoperfusion and are indicative of severe illness, especially in critically ill patients. Monitoring the underlying causes of elevated lactate is crucial to prevent further clinical deterioration. Lactate measurements are typically obtained through arterial blood gas analysis at the time of ICU admission, as well as at 24 and 48 hours post-admission. High lactate levels at admission are strongly linked to increased ICU mortality. Patients with elevated lactate are more likely to develop multi-organ dysfunction and require intensive organ support, such as vasopressors and mechanical ventilation. Importantly, admission lactate levels are an independent predictor of poor outcomes, even when adjusted for established severity scoring systems like APACHE II and SOFA. Thus, early identification of elevated lactate can provide valuable prognostic information in the management of critically ill patients
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •patient with elevated lactate levels.
- •clinical conditions associated with tissue hypoxia and systemic disease.
- •all consecutive critically ill adult age above 19 years.
排除标准
- •neonates and paediatric patients.
- •incomplete records or missing data.
结局指标
主要结局
Development of multi organ dysfunction syndrome(MODS)
时间窗: 8weeks
lactate clearance and its association with clinical deterioration
时间窗: 8weeks
factors enchance lactate clearance at 24 hours and at 48 hours
时间窗: 8weeks
abg
时间窗: 8weeks
serum lactate
时间窗: 8weeks
apache 2 score and sofa score
时间窗: 8weeks
次要结局
- length of ICU stay(need for organ suport(mechanical ventilation, vasopressors))
研究者
Pavithradevi S
Sri Ramachandra Institute of Higher Education and Reasearch