Dynamic Full-Field Optical Coherence Tomography for Structural and Microbiological Characterization of Central Venous Catheter-deposited Biofilm in Critically Ill Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- D-FF-OCT-based biofilm structure type
研究概览
简要总结
29.3% of bacteremias in intensive care units (ICU) are linked to vascular devices, with a significant proportion related to central venous catheters, and an influence on both morbility and mortality.
It is now accepted that microbiological biofilm plays a key role on both bacterial and fungal development on inner surface of vascular devices but there is yet a lack of clinical relevant data documenting a causal relation between biofilm formation and bacteremias.
We assume that a more precise characterization of central venous catheter-deposited biofilm could help us better understand invasive medical device-related healthcare infections in critically ill patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient or relative informed of the study and having declared their nonobjection
- •Patient over 18 years of age
- •Patient exposed to central venous catheter for at least two calendar days
排除标准
- •Patient unable to declare their nonobjection
- •Patient whose central venous catheter collection is impossible
- •Patient admitted in ICU with a central venous catheter already in place
结局指标
主要结局
D-FF-OCT-based biofilm structure type
时间窗: At Day 0, within 24h following catheter removal
Biofilm structure type (ribbon-shaped or mushroom-shaped), measured with D-FF-OCT
次要结局
- D-FF-OCT-based biofilm thickness(At Day 0, within 24h following catheter removal)
- D-FF-OCT-based dynamic signal distribution(At Day 0, within 24h following catheter removal)