NCT05370664尚未招募不适用
Performance of Novel Bed Side Scores as Predictors of Hospital Outcome in Acute Exacerbation of Chronic Obstructive Pulmonary Disease Among Women; Cohort Study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 203
- 主要终点
- Mortality rate among COPD patients hospitalized due to acute exacerbation.
研究概览
简要总结
- Assess predictors of mortality in COPD exacerbation between men and women.
- Evaluate the clinical outcomes in acute exacerbation of COPD in women.
- Evaluate the validity of new scoring systems ( NIVO, DECAF, HACOR ) as a predictor for hospital outcome in acute exacerbation of COPD.
- Compare these new scoring system with the most widely used APACHE IV.
- Assessment of serum level of granulocyte colony stimulating factor ( GM-CSF) in detecting the severity of COPD exacerbation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 35 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with AECOPD leading to hypoxemia, hypercapnia and respiratory acidosis with pH < 7.35 and PaCO2 > 45 mm of Hg will be admitted to the respiratory intensive care unit (ICU) for NIV or the ward will be eligible for inclusion and not in need for mechanical ventilation
排除标准
- •Requirement for emergency intubation.
- •Other contraindications to NIPPV including cardiac or respiratory arrest; nonrespiratory organ failure (eg, severe encephalopathy, severe gastrointestinal bleeding, hemodynamic instability with or without unstable cardiac angina); facial surgery or trauma; upper-airway obstruction; inability to protect the airway and/or high risk of aspiration; and inability to clear secretions.(6)
- •Age < 35 years.
结局指标
主要结局
Mortality rate among COPD patients hospitalized due to acute exacerbation.
时间窗: 28 days from admissiom
Assessment of mortality with different scoring systems in acute exacerbation of COPD
Early prediction of NIV failure.
时间窗: 48 hours from ICU admission
Using NIVO score for Acute exacerbaion of COPD Non-invasive ventilation outcomes score is considered to be Low risk ( 0-2) Moderate risk (3-4) High risk (5-6) Very high risk ( 7-9)
Assessment of GM-CSF as a biomarker for successful therapy in acute exacerbation of COPD.
时间窗: baseline
Assessment of granulocyte colony stimulating factor by ELISA test in acute exacerbation of COPD
次要结局
- Assisted ventilation days.(Baseline)
研究者
Khaled Essmat Hussien
Assistant Lecturer of chest diseases and tuberculosis
Assiut University
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