CALVIH: Determination of Kidney Stone Risk Factors in Patients Infected With HIV
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- Qualitative assessment of the cause of the renal stone
研究概览
简要总结
The purpose of this study is to define the cause of renal stones and the risk pattern for recurrence of renal stones episodes (any kind of stones) in HIV1 patients.
详细描述
This study aims at defining the cause of renal stones and the risk pattern for recurrence of renal stones episodes (any kind of stones) in HIV1 patients.
Primary Objective :
- Finding the cause of renal stone in HIV patients defined as stone composition if stone is available or more probable pathophysiological mechanism
- Risk profile for stone recurrences estimated on risk indices in HIV1 patients
Secondary Objective(s)
- Identify prevalence of recurrences and describe co-morbidities associated with stone disease
- Describe urological management for renal stones in HIV patients
- Describe the causes of drug induced renal stones
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult male or female HIV1 infected patients willing to participate in the study
- •Having experienced a renal stone episode within the past six months or living with a renal stone
- •Able to understand the protocol
- •Giving oral consent
排除标准
- •CT scan impossible
- •Follow up impossible over 1 year
结局指标
主要结局
Qualitative assessment of the cause of the renal stone
时间窗: at 6 months
Qualitative assessment of the cause of the renal stone based on different biological and clinical parameters (biochemical analysis of urines, cristalluria, low dose renal CT, patient history, family history...)
Risk profile for recurrence of renal stone
时间窗: at 12 months
Risk profile for recurrence of renal stone estimated based on plasma and urinary parameters, nutritional profile and drug exposure
次要结局
- Follow up outcome of HIV patients over one year to identify prevalence of recurrences and describe co-morbidities associated with stone disease(up to 12 months)
- Causes of drug induced renal stones(up to 12 months)
- Number of stone recurrences(at 12 months)
- Urological management for renal stones in HIV patients(up to 12 months)
研究者
Corinne Isnard Bagnis
University Professor and Hospital Practitioner
Association pour le Developpement d'Investigations et de Thérapeutiques en Néphrologie