Vasodilation Effect of Inhalational Anesthetics Including Halothane, Isoflurane, Sevoflurane, Desflurane and Enflurane
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Ultrasonography of blood vessels including radial artery, brachial artery, femoral artery, popliteal artery
研究概览
简要总结
Previous studies on animals suggest that inhalational anesthetics can reduce vascular tension in vitro resulting in vasodilation and decrease in blood pressure. This role for inhalational anesthetics has essential clinical implications such as the condition of sepsis or septic shock or other shock-associated states during which the blood vessel constricts strongly and leads to circulation dysfunction. The vasodilation property of these anesthetics including halothane, isoflurane, sevoflurane, desflurane and enflurane enables them to be better options than other general anesthetics in many clinical conditions needing the vasculature to be dilated. The investigators hypothesized that these inhalational anesthetics can evoke vasodilation measured with ultrasonography during general anesthesia in vivo as the in vitro studies displayed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Must be undergoing general anesthesia
- •Age between 19-45 years
排除标准
- •With hypertension
- •Existing organic dysfunction
- •Allergic to inhalant anesthetics
- •Alcohol addictive or narcotic dependent patients
- •A history of the use of centrally-acting drugs of any sort, chronic pain and psychiatric diseases records
研究组 & 干预措施
1
Halothane anesthesia: induction and maintenance with different doses
干预措施: Halothane (Drug)
2
Isoflurane anesthesia: induction and maintenance with different doses
干预措施: Isoflurane (Drug)
3
Sevoflurane anesthesia: induction and maintenance with different doses
干预措施: Sevoflurane (Drug)
4
Desflurane anesthesia: induction and maintenance with different doses
干预措施: Desflurane (Drug)
5
Enflurane anesthesia: induction and maintenance with different doses
干预措施: Enflurane (Drug)
结局指标
主要结局
Ultrasonography of blood vessels including radial artery, brachial artery, femoral artery, popliteal artery
时间窗: Ten min prior to anesthesia; 0 min of anesthesia; 0 min of the end of anesthesia induction; 5, 10, 20, 30, 60 min during maintenance of the anesthesia
次要结局
- The time interval of between the initiation of the inhalational anesthetics delivered to the beginning of decreasing of blood pressure(From the beginning of anesthesia (0 min) till the first time of blood pressure decreased, this measure would be varied according to different individuals)
- The total dose of phenylephrine required to maintain baseline arterial blood pressure(From the beginning of anesthesia (0 min) to 20 min after anesthesia begun)
- Blood flow volume during anesthesia of the vasculature(Ten min prior to anesthesia; 0 min of anesthesia; 0 min of the end of anesthesia induction; 5, 10, 20, 30, 60 min during maintenance of the anesthesia)
- Blood pressure including systolic, diastolic and mean artery blood pressures(Ten min prior to anesthesia; 0 min of anesthesia; 0 min of the end of anesthesia induction; 5, 10, 20, 30, 60 min during maintenance of the anesthesia)
- Regression and correlation analyses between different doses of the anesthetics and the extent of vasodilation(Forty eight hours after operation)