Identifying Factors Influencing In-Hospital Relapse in Pemphigus Patients: A Retrospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 96
- 试验地点
- 1
- 主要终点
- in-hospitalization relapse
研究概览
简要总结
The objective of this retrospective study was to investigate the factors influencing in-hospital relapse during acute episodes of pemphigus, an autoimmune blistering disease characterized by self-antibodies targeting desmogleins. The study included 96 pemphigus patients hospitalized in China between January 2014 and December 2020. The primary questions addressed by the study were:
What are the risk factors associated with in-hospital relapse during acute episodes of pemphigus? Participants in the study underwent a retrospective analysis using univariate and multivariate Cox regression analysis to identify and understand the various risk factors contributing to in-hospital relapse. This research aimed to contribute valuable insights into the factors influencing the course of pemphigus, providing crucial information for better management and treatment strategies.
详细描述
This retrospective study conducted in China between January 2014 and December 2020 aimed to comprehensively examine factors influencing in-hospital relapse during acute episodes of pemphigus, an autoimmune blistering disease characterized by self-antibodies targeting desmogleins-essential cell adhesion molecules. The study enrolled 96 pemphigus patients who were hospitalized during acute episodes.
Research Questions:
Primary Question:
What are the identifiable risk factors associated with in-hospital relapse in pemphigus patients during acute episodes?
Methods:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 80 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •inpatients.
- •Pathologic diagnosis of pemphigus.
排除标准
- •Patients hospitalized for cyclophosphamide shock therapy only.
- •Patients who did not recover and were discharged due to personal reasons.
结局指标
主要结局
in-hospitalization relapse
时间窗: through hospitalization (Up to 1 month)
the occurrence of in-hospital relapse among pemphigus patients during acute episodes
次要结局
未报告次要终点
研究者
Hanyi Wu
doctor
First Affiliated Hospital of Chongqing Medical University