NCT03259659终止不适用
Autonomic and Cytokines Profiles of Patients With Ulcerative Proctitis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- symptoms characteristics in ulcerative colitis patients
研究概览
简要总结
- To prove that patients with ulcerative proctitis and proctosigmoiditis have impaired autonomic functions, i.e. increased sympathetic activity and/or reduced vagal tone.
- To demonstrate inflammatory cytokine imbalance, i.e., increased pro-inflammatory cytokines. Presence of these abnormalities would make patients with ulcerative proctitis and proctosigmoiditis good candidates for future sacral nerve stimulation therapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •No any systemic diseases;
- •no proctitis or proctosigmoiditis;
- •no history of gastrointestinal surgery;
- •no symptoms of diarrhea or fecal urgency during the past 2 weeks;
- •not taking any medications except contraceptives during the past 2 weeks;
- •age 18-65.
排除标准
- 未提供
结局指标
主要结局
symptoms characteristics in ulcerative colitis patients
时间窗: 1 day
ulcerative colitis disease activity index will be assessed using the Mayo scoring system, which includes stool frequency, rectal bleeding, mucosal appearance at endoscopy and physician rating of disease activity. The patient will get a score from 0 to 20, with higher score indicating more severe disease.
次要结局
- autonomic profile characteristics in ulcerative colitis patients and healthy controls(1 day)
- microbiota profile in ulcerative colitis patients and healthy controls(1 day)
- inflammatory cytokine profile in ulcerative colitis patients and healthy controls(1 day)
研究者
研究点 (1)
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