ACTRN12621001750875招募中未知
Autoimmune Encephalitis - a rare and debilitating neurological illness affecting the Australian population. A study by the Australian Autoimmune Encephalitis Consortium.
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 入组人数
- 240
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •* Confirmed or Antibody Positive Autoimmune Encephalitis:
- •* Possible Autoimmune Encephalitis:
- •Diagnosis can be made when all three of the following criteria have been met (Grause et al, 2016 criteria):
- •- Subacute onset (rapid progression of less than 3 months) of working memory deficits (short-term memory loss), altered mental status, or psychiatric symptoms
- •- At least one of the following:
- •* New focal CNS findings
- •* Seizures not explained by a previously known seizure disorder
- •* CSF pleocytosis (white blood cell count of more than five cells per mm3)
- •* MRI features suggestive of encephalitis
- •- Reasonable exclusion of alternative causes
- •* Other Neuroinflammatory Brain Conditions (ideally prior to steroid commencement)
- •- Neurosarcoidosis (with CNS involvement in setting of systemic sarcoid, or biopspy proven neurosarcoidosis)
- •- Cerebral vasculitis (that is biopsy proven)
- •- Neuromyelitis optica spectrum disorders
- •(anti aquaporin 4 or anti MOG positive disorders, or meeting the 2016 diagnostic clinical diagnostic criteria of NMO SD) with concomitant encephalitis / decreased conscious state or cognitive deficits
- •- Acute demyelinating encephalomyelitis
- •- Autoimmune seizures / possible autoimmune epilepsy / new onset refractory status epilepticus (NORSE)
- •- CNS lupus (with systemic and hematologic abnormalities diagnostic of lupus) and other neuroinflammatory brain conditions
- •- Or Other neuroinflammatory conditions - discuss with central coordinator / CPI
- •* Healthy Volunteer
- •- Generally well
- •- not suffering from an autoimmune condition or other neurological condition
- •- no evidence of infection in the last two weeks
- •- not currently being treated with steroids
排除标准
- •Infective encephalitis
研究者
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