Characterization of Immune-response in Autoimmune Encephalitis and Paraneoplastic Neurological Syndromes
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Autoimmune Encephalitis
- 发起方
- Hospices Civils de Lyon
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Correlation between biological results and clinical data
- 状态
- 招募中
- 最后更新
- 3年前
概览
简要总结
Autoimmune encephalitis (AE) and paraneoplastic neurological syndromes (PNS) are rare neuroimmune syndromes with a wide range of clinical presentation but without pathognomonic clinical sign facilitating the diagnosis. A lot of differential diagnoses are possible such as neurodegenerative diseases or viral infections. Although rare the diagnosis of AE or PNS is essential because despite severe neurological symptoms, patients can be cured by appropriate immunotherapy. Autoantibodies highly specific of AE and PNS has been described in the serum and cerebrospinal fluid of the patients and can be used as biomarkers of the disease. Their presence can predict an autoimmune origin and in many cases a good prognosis after immunotherapy. However, if some autoantibodies are now well-characterized and industrial kits have been developed to detect them, in numerous cases of highly suspect AE or PNS no specific autoantibodies are identified leading frequently to an inappropriate treatment. Furthermore, as the mechanisms of AE and PNS is still unknown, treatments are not optimal and in some cases inefficient. There is no prognosis biomarker able to predict the patient's sensitivity to immunotherapy and there are only few clues to know how the immune system can provoke the neuropsychiatric symptoms observed in the patients.
研究者
入排标准
入选标准
- •Patient with neurological disorder
- •Patient with antibodies or not in sera or CSF
排除标准
- •No available clinical data
结局指标
主要结局
Correlation between biological results and clinical data
时间窗: Through study completion, an average of 1year
This measure will compare the result of immunological and genetic makers with clinical data of each patient.