Observational Study Evaluating the Impact of Opioid Free Anesthesia During Lung Protective Ventilation on Postoperative Oxygen Saturation.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- oxygen requirement post operative to maintain saturation above 94%
研究概览
简要总结
Opioids used intra operative increase the amount of opioids needed post operative to control post operative pain. if opioids are given post operative, we assume that more atelectasis and hypoxia takes place even after lung protective ventilation. These postoperative lower oxygen saturations will require giving more frequent oxygen therapy.
详细描述
This is an observational study where the attending anesthesiologist decides to use opioid free or opioid general anesthesia based on his/her expertise.
Every patient gets a lung protective ventilation and emergence from anesthesia using the principles set forward in the consensus meeting by Young C BJA 2019.
A lung recruitment followed by high PEEP is given when lung compliance decreases below 40 ML/cmH20. The lowest oxygen saturation without adding oxygen therapy is noted post extubation at moment of admission in PACU, after having given an opioid as analgesic and at moment of discharge from PACU..
If post operative satuation drops below 94% oxygen therapy is given and noted.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •major surgery where intubation with mechanical ventilation is required
- •obese patients with BMI > 35
排除标准
- •spontaneous breathing during procedure
- •allergic to any of the drugs used in both groups
- •severe liver, renal, cardiac or pulmonary disease
结局指标
主要结局
oxygen requirement post operative to maintain saturation above 94%
时间窗: first 24 hours post operative
oxygen saturation
次要结局
- postoperative pain(first 24 hours post operative)
- postoperative opioid consumption(first 24 hours post operative)