Study of coronary culprit lesion characteristics by Optical Coherence Tomography in patients presenting with Acute Coronary Syndrome

DrBasant Kumar0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

试验速览

暂无简介。

•1. Age > 18 years
•2. Patients presenting with 1st or recurrent event of acute coronary syndrome ( ACS), unstable angina (USA), non â??ST elevation myocardial infarction ( NSTEMI ), ST elevation myocardial infarction (STEMI)
•3. ACS as trigger event - (ESC guidelines) being:
•1. Acute cardiac chest pain or angina equivalent consistent with moderate to high-risk unstable angina or myocardial infarction, lasting more than 10 minutes duration during 72 hours before invasive examination AND/OR
•2. Evidence for ACS requiring catheterization documented by a) elevated enzymes (CK-MB or hs-Troponin I/T > 99th percentile or in-/decrease) AND/OR
•3. ECG with ST-depression >1mm in 2 or more contiguous leads after the J-point AND/OR transient ST-elevation >1mm in 2 or more contiguous leads lasting <30 min OR c) STE-ACS with onset < 24 hours previously and chest pain >30 min ST-elevation >1mm in 2 or more contiguous leads or new left bundle block.
•4. Written informed consent

•EXCLUSION CRITERIA
•1. Known systolic heart failure with left-ventricular ejection fraction (LV-EF<= 30 %).
•2. Cardiogenic shock or heart failure requiring intubation, inotropes; diuretics or mechanical circulation support.
•3. Refractory ventricular arrhythmia requiring pharmacologic or defibrillator therapy.
•4. Renal insufficiency with serum-creatinine >= 1.5 mg/dl.
•5. ACS with culprit lesion in a bypass graft.
•6. No suitable anatomy of culprit lesion for OCT:
•o severe calcification or extreme tortuosity of culprit lesion.
•o culprit lesion with very distal location.
•o infarct vessels with an diameter > 4 mm or < 2 mm.
•7. TIMI flow <= 2

发起方

DrBasant Kumar