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临床试验/NCT06384365
NCT06384365已完成不适用

Interaktion Von Ausgewählten Inflammationsparametern, Geschmackswahrnehmung Und Geschmackspräferenzen in Abhängigkeit Von Physischer Aktivität Und Körperzusammensetzung

University of Vienna1 个研究点 分布在 1 个国家目标入组 64 人开始时间: 2024年4月15日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
64
试验地点
1
主要终点
Body composition

研究概览

简要总结

The aim of this study is to investigate whether differences in taste perception and preference behavior can be attributed to inflammatory processes induced by physical activity. The focus will be on sweet taste and the perception of fat. A non-invasive, observational study design will be used.

详细描述

This study adresses the question of whether there is a connection between low-grade inflammation caused by physical activity and a change in taste perception and preference for the sweet taste. The taste perception, preference behavior and inflammation in athletic and healthy non-athletic subjects using an observational study design is investigated.

The hypothesis is that athletic test subjects, compared to healthy, physically inactive subjects, show increased inflammation values, in the range of a low-grade inflammation, and that this results in a lower sensitivity and increased preference for sweet taste.

The primary parameters to be investigated are a possible correlation between the level of physical activity physical activity or body composition and the recognition threshold for the sweet taste as well as the preference. In addition, a correlation between the concentration of TNF-α and IL-6 in saliva sweet recognition threshold and sweet preference will be investigated.

Secondary parameters to be analyzed are the preference for fatty substances, the perception threshold for the perception threshold for the fatty taste, taste receptors in saliva for the sweet and fatty taste, the concentration of 8-epi-PGF2α in the urine as a marker for oxidative stress, and the number of fungiform papillae on the tongue are determined.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 45 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • non-smoking
  • normal taste and smell perception

排除标准

  • pregnancy or breast-feeding
  • regular smokers
  • regular intake of medication
  • metabolic diseases that require drug therapy
  • ageusia or anosmia
  • alcohol or drug addiction
  • intake of antibiotics within the past 2 months
  • vegan diet
  • viral or bacterial infection wihtin the past three weeks

结局指标

主要结局

Body composition

时间窗: day 1

body fat percentage

Low-grade inflammation

时间窗: day 1

Concentration of interleukin 6 and tumor necrosis factor alpha in unstimulated saliva

Taste sensitivity

时间窗: day 1

detection threshold for sweet and fatty taste analysed using a 3-AFC test

Taste preference

时间窗: day 1

preference for sweet and fatty taste analyzed by means of a Food Frequency Questionnaire and food choices from a standardized breakfast

次要结局

  • fungiform papillae density(day 1)
  • Oxidative Stress(day 1)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Barbara Lieder

Professor and Vice Chair Department of Physiological Chemistry

University of Vienna

研究点 (1)

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