Intraarticular Injections of the Hip and Knee With Triamcinolone Versus Ketorolac: A Randomized Controlled Trial
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Change in Visual Analogue Scale (Baseline to One Week Post-injection)
研究概览
简要总结
Clinicians commonly utilize intraarticular injections to treat symptomatic primary arthritis. Steroid injections are common yet have immune-modulating effects and can alter gene expression which may delay definitive arthroplasty and further damage cartilage. Non-steroidal anti-inflammatory (NSAID) injections may offer a safer profile due to their differing mechanism of action; however, there is a relative dearth of information regarding their efficacy. This non-inferiority study compares the effectiveness of triamcinolone versus ketorolac in treating symptoms of moderate to advanced primary osteoarthritis of the hip and knee.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Symptomatic, radiographically proven degenerative joint disease in the hip or knee
排除标准
- •recent injection in the hip or knee within the previous 3 months
- •history of traumatic osteoarthritis or ligamentous reconstruction
- •chronic narcotic use
- •history of inflammatory or neuropathic arthropathy
- •pregnant and/or nursing women
- •allergy or strong reaction to study medications
研究组 & 干预措施
Ketorolac Intraarticular Hip Injection
Patients will receive an intraarticular hip injection with ketorolac.
干预措施: Ketorolac Intraarticular Injection (Drug)
Triamcinolone Intraarticular Hip Injection
Patients will receive an intraarticular hip injection with triamcinolone.
干预措施: Triamcinolone Intraarticular Injection (Drug)
Ketorolac Intraarticular Knee Injection
Patients will receive an intraarticular knee injection with ketorolac.
干预措施: Ketorolac Intraarticular Injection (Drug)
Triamcinolone Intraarticular Knee Injection
Patients will receive an intraarticular knee injection with triamcinolone.
干预措施: Triamcinolone Intraarticular Injection (Drug)
结局指标
主要结局
Change in Visual Analogue Scale (Baseline to One Week Post-injection)
时间窗: Comparing baseline to one week post-injection
Pain Score
Change in PROMIS Global Health Scores (Baseline to One Month Post-injection)
时间窗: Comparing baseline to one month post-injection
Overall patient wellbeing
Change in Visual Analogue Scale (Baseline to One Month Post-injection)
时间窗: Comparing baseline to one month post-injection
Pain Score
Change in Visual Analogue Scale (Baseline to Three Months Post-injection)
时间窗: Comparing baseline to three months post-injection
Pain Score
Change in PROMIS Global Health Scores (Baseline to One Week Post-injection)
时间窗: Comparing baseline to one week post-injection
Overall patient wellbeing
Change in PROMIS Global Health Scores (Baseline to Three Months Post-injection)
时间窗: Comparing baseline to three months post-injection
Overall patient wellbeing
Change in Knee Injury and Osteoarthritis Outcome Score Jr. (Baseline to One Week Post-injection)
时间窗: Comparing baseline to one week post-injection
Functionality and pain of affected knee
Change in Knee Injury and Osteoarthritis Outcome Score Jr. (Baseline to One Month Post-injection)
时间窗: Comparing baseline to one month post-injection
Functionality and pain of affected knee
Change in Knee Injury and Osteoarthritis Outcome Score Jr. (Baseline to Three Months Post-injection)
时间窗: Comparing baseline to three months post-injection
Functionality and pain of affected knee
Change in Hip Injury and Osteoarthritis Outcome Score Jr. (Baseline to One Week Post-injection)
时间窗: Comparing baseline to one week post-injection
Functionality and pain of affected hip
Change in Hip Injury and Osteoarthritis Outcome Score Jr. (Baseline to One Month Post-injection)
时间窗: Comparing baseline to one month post-injection
Functionality and pain of affected hip
Change in Hip Injury and Osteoarthritis Outcome Score Jr. (Baseline to Three Months Post-injection)
时间窗: Comparing baseline to three months post-injection
Functionality and pain of affected hip
次要结局
未报告次要终点
研究者
Kevin Jurgensmeier
Medical Student
Saint Alphonsus Regional Medical Center