JPRN-UMIN000017581招募中未知
Quantitative followup study of the driver mutation fraction in cell-free DNA from non small cell lung cancer patient during TKI therapy - Quantitative followup study of the driver gene mutation in cell-free DNA
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 入组人数
- 39
研究概览
简要总结
Methods: 33 cfDNA samples from patients who received EGFR-TKI therapy for tumor with sensitive mutations were subjected to a pdPCR-based examination of the proportion of sensitive mutant cfDNAs with the T790M mutation. Results: sensitive mutations were detected in all 8 samples obtained after acquisition of resistance to TKIs and T790M mutation were positive in 5 of the samples. Conclusions: pdPCR-based examination of cfDNAs represents a robust non-invasive assessment of tumor progression status.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 20years-old 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1)Patient who need other anti-malignant medicine, radiotherapy or immunity. 2)Patient with positive HBs antigen and HBV-DNA. 3)Patient with definite positive HIV antibody (need not for examination). 4)Patient with other active cancer (except cancer treated without recurrence in more than 5 years and after carcinoma complete excision in situ) 5)TPatient with interstitial pneumonia 6)Any other patients who are regarded as unsuitable for this study by the investigators.
研究者
相似试验
已完成
不适用
Monitoring study of genomic mutations in patients with EGFR mutation or ALK translocation using plasma DNAnon-small-cell lung cancerJPRN-UMIN000035628Wakayama Medical University100
Unknown
不适用
A Retrospective EGFR Mutation Status Study in Chinese NSCLC Patients Using Paired Plasma and Tissue SamplesCarcinoma, Non-Small-Cell LungNCT01382992Peking Union Medical College Hospital150
Unknown
不适用
A Retrospective Molecular Epidemiology Study in Singapore Patients With Advanced Non Small Cell Lung Cancer (NSCLC) of Adenocarcinoma Histology to Assess Epidermal Growth Factor Receptor (EGFR) Mutation StatusNSCLCNCT01100827National University Hospital, Singapore
已完成
不适用
EGFR Mutations on ctDNA in Patients With Advanced NSCLCNon-small Cell Lung Cancer Stage IIINon-Small-Cell Lung Cancer MetastaticNCT02623257First People's Hospital of Hangzhou1,055
Unknown
不适用
IMRT and Timing in Combination With EGFRTKI for Stage IV Non-small-cell Lung CancerNonsmall Cell Lung CancerCarcinoma, Non-Small-Cell LungNon-Small Cell Lung CancerNCT03258671LuBing160