Improved Orthostatic Tolerance = Better Cognitive Function in Parkinson's Disease: Does a Successful Treatment of Orthostatic Hypotension Measurably Enhance Attention and Memory Functions in Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Blood Pressure in mmHg
研究概览
简要总结
Study on orthostatic Hypotension in Parkinson's disease
详细描述
Orthostatic hypotension (OH) in Parkinson's disease (PD) may not only be related to dizziness or light headedness but to deficits in attention, visual, and verbal memory. Would a successful treatment of OH which includes physiotherapy significantly improve OH and these cognitive deficits? By means of a randomized cross-over trial, we want to measure and compare the effects of OH therapy on orthostatic tolerance, as well as on attention, visuo-spatial working memory, and verbal memory in patients with PD. If confirmed, therapy of orthostatic hypotension would provide a sound and simple approach to improve those cognitive deficits originating from orthostatic hypotension.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 40 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Parkinson's patients
- •Diagnostis of OH
- •able to perform an ambulatory physiotherapy at Aachen University Hospital.
排除标准
- •deep brain stimulation or Pacemaker
- •severe psychiatric disease
- •severe heart disease
- •severe vascular encephalopathy
- •pregnant or lactating women
- •extreme pain or immobility
结局指标
主要结局
Blood Pressure in mmHg
时间窗: 10months
Systolic postural blood pressure drop in the interventional Group (Long_Physiotherapy) less than 10mmHg (5-15mmHg) compared to Short_Physiotherapy
次要结局
- Orthostatic symptoms (Winkler Scale)(10months)
- daytime sleepiness(10months)
- Attention in TAP(10months)
研究者
Andrea Maier
attending physician and investigator
RWTH Aachen University