NCT07194915进行中（未招募）不适用
Pleural Fluid Neutrophil Extracellular Traps Exacerbate Disease Severity and Risk of One-year Mortality in Pleural Infection: An Observational, International, Multicohort Study (TORPIDS-3)
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 326
- 试验地点
- 1
- 主要终点
- Disease severity
研究概览
简要总结
Pleural infection is a severe and complicated disease which is associated with significant morbidity and mortality. People with pleural infection show diverse levels of neutrophil degranulation activity. The investigators examined the biological role of pleural fluid neutrophil extracellular traps in patients with pleural infection. TORPIDS-3 is an observational, International multicohort study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients were included if they had a clinical presentation consistent with pleural infection as stated in the Methods section of the main manuscript and any of the following criteria:
- •Pleural fluid that was macroscopically purulent, OR
- •Pleural fluid that was positive on culture for bacterial infection, OR
- •Pleural fluid that demonstrated bacteria on Gram staining, OR
- •Pleural fluid with pH ≤7.2 (measured in a blood gas analyser) or low glucose level (≤3mmol/L or ≤55mg/dL) in a patient with clinical evidence of infection, OR
- •Contrast-enhanced CT evidence of pleural infection (consolidation of underlying lung with enhancing pleural collection) in a patient with clinical evidence of infection, alongside exclusion of other sources of infection.
- •Exclusion criteria:
- •Age less than 18 years, OR
- •No pleural fluid available for analysis, OR
- •Patient previous pneumonectomy on the side of pleural infection, OR
- •Expected survival less than three months due to co-morbid disease, as judged by the recruiting physician
排除标准
- 未提供
结局指标
主要结局
Disease severity
时间窗: Baseline
Association between pleural fluid NETs with disease severity
One-year mortality
时间窗: Baseline
Association between pleural fluid NETs and risk of one-year mortality
次要结局
- Need for Intrapleural Enzyme Therapy (IET)(Baseline)
- Bacterial profiles(Baseline)
- Sonographic septations(Baseline)
研究者
研究点 (1)
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