ITMCTR1900002614尚未招募1 期
Clinical observation of Zhenwu decoction in the treatment of refractory cirrhosis ascites
Second Department of Hepatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine0 个研究点开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 尚未招募
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional study
入排标准
- 年龄范围
- 18 至 80（—）
- 性别
- All
入选标准
- •1. Western medicine standard reference guidelines for diagnosis and treatment of cirrhosis and related complications of hepatology branch of the Chinese medical association (2017 edition):
- •(1) decompensated cirrhosis (child-pugh grade B/C).
- •(2) obvious signs of abnormal liver function and decompensation, such as serum albumin <35g/L; Or obvious jaundice, bilirubin >35 micron /L; Or elevated ALT and AST;Or prothrombin activity <60%; The patient has ascites.
- •(3) imaging diagnosis showed that the liver surface was obviously uneven, zigzag or wavy, the liver edge became blunt, the echo of liver parenchyma was uneven and enhanced, and it was nodular, the inner diameter of portal vein and splenic portal vein was widened, the blood vessels in the liver were not clear, and the liquid dark area was visible in the abdominal cavity.
- •(4) large diuretic drugs (160mg/d in whelk and 80mg/d in furfurmi) were treated for at least 1 week or intermittent therapeutic ascites (4000-5000ml/ time) combined with albumin (20-40g/ time/day) for ascites for 2 weeks without any response to treatment;Difficult to control diuretic drug - related complications or adverse reactions.
- •2. TCM standard reference 2017 cirrhosis ascites medical diagnosis and treatment Zhuangjie consensus opinion, in line with the Chinese medicine bulging diagnostic criteria, that is, abdominal fullness, short urine, and even abdomen as a drum, skin color pale, vein exposure as the main performance. The syndrome type conforms to the syndrome of spleen and kidney yang deficiency.
- •Main symptoms: (1) abdominal fullness, shape like frog belly; (2) abdominal distension early light weight; (3) limb cold;
- •secondary symptoms: (1) complexion white; (2) limb edema; (3) waist and knees soft; (4) cold pain in the abdomen.
- •Diagnosis: 2 cases with major symptoms plus 2 minor cases, or 1 case with major symptoms plus 3 minor symptoms.
排除标准
- •Exclusion criteria are those that do not meet any of the inclusion criteria; patients with severe cardiovascular, pulmonary, renal, or neurological diseases and severe primary hematological diseases, as well as patients with mental illness, tumors (hepatic tumors only exclude concurrent ascites); renal insufficiency Diabetes patients with uncontrolled blood sugar; pregnant and lactating women. Liver cirrhosis complicated with upper gastrointestinal bleeding, hepatic encephalopathy, and patients with hepatorenal syndrome.
研究者
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