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临床试验/NCT00300209
NCT00300209已完成不适用

Manhattan HIV/Hepatology Brain Bank

Icahn School of Medicine at Mount Sinai1 个研究点 分布在 1 个国家目标入组 187 人开始时间: 1998年9月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
187
试验地点
1
主要终点
Viral Load blood level

研究概览

简要总结

Description: The Manhattan HIV/Hepatology Brain Bank (MHBB) was established in 1998 as a resource for the AIDS research community. The MHBB was created to act as a center for the provision of pre- and post-mortem tissues and body fluids from HIV infected persons. It has recently expanded its goals to assist in the elucidation of liver disease-induced nervous system disorders.

The MHBB is dedicated to improving the understanding of HIV and Hepatitis C and thereby, improving the lives of patients living with HIV and/or Hepatitis C.

Participation is voluntary and can be stopped at any time.

Benefits: This is an observational study; no experimental procedures, devices or drugs are used. All enrolled patients undergo regular examinations by physicians, nurses, and neuropsychologists who specialize in the problems that HIV and HCV can cause.

Taking part in this study may result in the detection of brain, muscle, or spinal cord disease for which treatments may be available. Participants may receive no direct benefit from this study. However, knowledge gained from this research may, in the future, help others who suffer from HIV/AIDS and/or liver disease.

Participants agree to autopsy and organ donation upon demise by signing an Anatomical Gift Consent document.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • CD4 < 50 on two occasions >12 weeks apart. Hemoglobin <10 G/dL. Albumin <3.2 G/dL.
  • CMV end-organ disease Disseminated MAC PML AIDS Dementia Complex Wasting (>30% of lean body mass)
  • Visceral Kaposi's sarcoma Lymphoma-systemic of CNS
  • CHF Major systemic illness with poor prognosis (as determined by primary physician).

排除标准

  • <18 years old Not willing to sign an Anatomical Gift Consent for autopsy and organ donation upon demise.

结局指标

主要结局

Viral Load blood level

时间窗: Baseline

Plasma viral load level

次要结局

  • CD4 cell blood level(Baseline)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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