Salivary Replication of BK Virus in Post-kidney Transplant
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Number of BK positive saliva and blood samples
研究概览
简要总结
BK virus infection in kidney transplantation can compromise graft function. Current data suggest that BK virus nephropathy results not only from transmission of virus from the donor but also from reactivation of latent virus in the recipient. However, no study has investigated the possibility of respiratory transmission. This study would provide a better understanding of the pathophysiology of BK virus infection in kidney transplant recipients. The investigators would study viral replication of BK virus in saliva, urine and blood of patients who received a kidney transplant at the Amiens University Hospital. For this, the investigators will collect salivary self-collection on the day of the kidney transplant then at 1, 3, 6, 9 and 12 months as well as a urine and blood sample. The investigators will measure BK viral load in these three samples at different times.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •kidney transplant recipients
- •age ≥ 18 years
排除标准
- •age < 18 years
- •absence of consent
结局指标
主要结局
Number of BK positive saliva and blood samples
时间窗: 12 months
Compare the positivity of the BK virus viral load between the saliva sample and the urine and blood samples
次要结局
- urinary BK virus concentration(12 months)
- variation of BK virus genome(12 months)
- Immunoglobin concentrations(12 months)