Behavioral Treatment for Cocaine Dependent Women
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 145
- 试验地点
- 4
- 主要终点
- Cocaine abstinence
研究概览
简要总结
To compare the efficacy of Community Reinforcement Approach (CRA) and 12-Step Facilitation (TSF) counseling and of voucher based reward therapy (VBRT) and a yoked, non-contingent voucher control (VC) for the treatment of cocaine dependent pregnant women or women with young children.
详细描述
Subjects were randomly assigned to 1 of 4 treatment groups (CRA+VBRT, CRA+VC, TSF+VBRT, TSF+VC). VBRT voucher value increased for each successive cocaine-free urine sample obtained twice weekly during the 1st 12 weeks and was faded from the final earned value to $5 during the last 12 weeks. All subjects earned vouchers for attendance at scheduled twice weekly counseling sessions. Manual-guided CRA and TSF were provided by experienced clinicians.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Pregnant women meeting DSM IV criteria for cocaine dependence
- •Women meeting DSM IV criteria for cocaine dependence with custody of a young child
排除标准
- •Opioid dependence
- •Psychosis
- •Severe depression
- •Current treatment with any anti-depressant or anti-psychotic medication
- •Medical instability
- •Inability to understand or read English
结局指标
主要结局
Cocaine abstinence
时间窗: 24 weeks
次要结局
- Reduced HIV risk behavior(24 weeks)