Effect of Growth Hormone on Early Brain Development in Girls With Turner Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 17
- 试验地点
- 1
- 主要终点
- Total Brain Volume
研究概览
简要总结
The purpose of this research study is to learn about brain development in very young girls with Turner syndrome (TS) and the effect that growth hormone (GH) therapy has on early brain development.
详细描述
Studies in older children and adults have found that IQ (intelligence quotient) in individuals with Turner syndrome (TS) and the general population are similar. However, many individuals with TS have a nonverbal learning disability which may cause problems with imagining and working with objects in space (for example: building blocks, working puzzles, copying designs, driving a car) as well as problems in planning, paying attention, and getting along with people their own age. Studies of brain structure have found changes in the size and function of specific areas of the brain that are involved in these nonverbal processes. However, there are no data published on brain structure or function in girls with Turner Syndrome in the first few years of life when brains are learning and growing most rapidly.
In a recent study, very young, short girls with Turner Syndrome (TS)(averaging 2 years in age) were treated with Growth Hormone (GH) and almost reached an average height after 2 years. The risks of GH for the young girls in that study appeared to be the same as those for older girls. Therefore, it is now recommended that GH therapy be considered as soon as a child with TS has growth failure. Growth failure often occurs during infancy; therefore, more children with TS are now receiving GH therapy as young as 12 months of age. In this study, the investigators wish to start understanding what effect GH has on learning and brain growth when given between the ages of 12 and 24 months. In this study, the girls with TS will have developmental studies, a physical examination, magnetic resonance imaging (MRI), and blood drawn at one and two years of age. Some of the girls in this study will receive GH from 12 until 24 months of life, while others will not. Brain growth and development will be compared between those who have been treated with GH and those who have not. This is a pilot study in which the investigators will gather data to design a larger study that can answer these questions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 11 Months 至 13 Months（Child）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of Turner syndrome
- •Less than the 50th percentile for length for the general female population
排除标准
- •Prior Growth Hormone (GH) therapy
- •Allergy to metacresol (a preservative in the GH liquid that is injected)
- •Contraindications for Magnetic Resonance Imaging (MRI) (such as metal in the body)
- •Part of a Y chromosome in child's karyotype
- •Parent/guardian is not willing for child to be randomized to be in the treatment group (receives Growth Hormone injections for one year) or the control group (receives no Growth Hormone during the study)
- •Parent/guardian is not willing for child to have some of her developmental testing digitally recorded for scoring
研究组 & 干预措施
Growth Hormone
Subjects in the somatotropin (growth hormone, GH) arm will receive GH injections from 12-24 months of life.
干预措施: somatotropin (Drug)
结局指标
主要结局
Total Brain Volume
时间窗: Change in volume from 12 months of age scan in 24 months of age scan
Percent change in total brain volume as determined by magnetic resonance imaging (MRI)
次要结局
- Volume of Brain Lobes (Central)(Change in volume from 12 months of age scan in 24 months of age scan)
- Volume of Brain Lobes (Temporal)(Change in volume from 12 months of age scan in 24 months of age scan)
- Volume of Brain Lobes (Insular Cortex)(Change in volume from 12 months of age scan in 24 months of age scan)
- Volume of Brain Lobes (Occipital)(Change in volume from 12 months of age scan in 24 months of age scan)
- Volume of Brain Lobes (Frontal)(Change in volume from 12 months of age scan in 24 months of age scan)
- Volume of Brain Lobes (Parietal)(Change in volume from 12 months of age scan in 24 months of age scan)
- White Matter Tracts (SLF)(Change in FA from 12 months of age scan in 24 months of age scan)
- Volume of Brain Lobes (Limbic)(Change in volume from 12 months of age scan in 24 months of age scan)
研究者
Rebecca Knickmeyer Santelli, PhD
Associate Professor
University of North Carolina, Chapel Hill