Microvascular Function in Non-ST-segment Elevation Acute Coronary Syndrome - DEFINE NSTEMI

Academisch Medisch Centrum0 个研究点目标入组 60 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

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•1. Stable angina (CCS class I to III, or Braunwald class I) or NSTE-ACS (Chest pain within the preceding 5 days and an index event >24 hours from time of angiography but within the previous 7 days).;2. Scheduled for percutaneous coronary intervention or intracoronary evaluation of functional stenosis severity (diagnostic catheterization).;3. The presence of at least one normal or minimally diseased reference coronary artery (<30% diameter stenosis on visual assessment) with a vessel diameter of more than 2.5 mm.

•1. Younger than 19 or older than 80 years of age.;2. Recent ST-segment elevation myocardial infarction (<6 weeks prior to enrollment).;3. Inability to receive intravenous adenosine (for example, severe reactive airway disease, marked hypotension, or high-grade AV block without pacemaker).;4. Known renal insufficiency (eGRF according to MDRD <30 mL/min/m2).;5. Known severe valvular abnormalities.;6. Known severe left ventricular dysfunction (LV ejection fraction <30%) or known myocardial hypertrophy (septal wall thickness at echocardiography of >13 mm).;7. Extremely tortuous or calcified coronary arteries precluding intracoronary physiologic measurements.;8. Women of child bearing age not on active birth control;9. Inability to sign an informed consent, due to any mental condition that renders the subject unable to understand the nature, scope, and possible consequences of the trial or due to mental retardation or language barrier.

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