New MRI Methods Applied to Heart Failure With Preserved Ejection Fraction (HFpEF)

University of Utah2 个研究点分布在 1 个国家目标入组 100 人开始时间: 2017年3月3日最近更新: 2026年7月7日

适应症

干预措施

试验速览

阶段: 1 期
状态: 招募中
发起方: University of Utah
入组人数: 100
试验地点: 2
主要终点: Image quality improvement

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This study's main specific aims are;

To develop robust acquisition and reconstruction methods specifically for the study of microvascular cardiac remodeling with MRI which will include very innovative quantitative perfusion methods, as well as fibrosis quantification, longitudinal strain, and phase contrast imaging for flow.
Test the new methods for identifying the clinical task of characterizing HFpEF.

详细描述

Heart failure with preserved ejection fraction (HFpEF) is currently being studied intensely as several large trials of drug therapies have failed to benefit patients. Better characterization of these patients is important, and there are open questions regarding microvascular disease and remodeling in the HFpEF population. New MRI methods could be ideal to better characterize and understand HFpEF and its response to treatments. This project seeks to develop, evaluate and apply new MRI methods for high-end perfusion imaging. These methods will estimate endo/epi ratios across the cardiac cycle in free-breathing studies, which will provide new information about microvascular disease. This is of particular value for assessing HFpEF.

The idea of this project is to combine new techniques for quantitative cardiac perfusion MRI imaging that would be ideally suited for answering open questions regarding HFpEF and for studying microvascular disease. The methods could potentially also predict patients who might respond to particular drug therapies.

The new techniques include "simultaneous multi-slice" imaging which has not been used this way for myocardial perfusion imaging. In particular, we are developing an innovative hybrid of the standard saturation pulse and steady state spoiled gradient echo acquisitions. We also are developing a new method for using 3D "stack of stars" + 2D slice in the same scan for arterial input function assessment to quantify perfusion, and new methods for measuring T1.

研究设计

研究类型: Interventional
分配方式: Na
干预模型: Single Group
主要目的: Health Services Research
盲法: None

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 是

入选标准

•All participants will be over the age of 18 and able to provide consent
•Group A (volunteers, with or without cardiac disease): Volunteers will be available for at least one study visit
•Group B (HFpEF patient volunteers): Volunteers will have a diagnosis of HFpEF and be safe to be imaged with MRI

排除标准

•Critically ill patients, patients on ventilators, patients with unstable angina or with hypotension, asthmatics, and other patients whose medical care or safety may be at risk from undergoing an MRI examination will be excluded.
•Patients with claustrophobia will also be excluded from the study if this cannot be controlled with standard methods (valium or benadryl).
•Patients with contraindication to MRI (metal implants, or certain types of heart valves),
•pregnant patients, , mentally disabled patients and prisoners will be excluded from this study. (All criteria apply to patients and normal volunteers).
•Gadolinium nephrotoxicity will be addressed by having patients with abnormal kidney function (GFR<30) excluded from the study due to the (very small) risk associated with gadolinium contrast agents.
•This threshold may be modified, depending on practices determined by the Radiology Department and the IRB.
•Patients with a known allergy or contraindication to Adenosine and/or Regadenoson will be excluded from stress MRI cohorts.
•All participants that will receive a stress agent will refrain from consuming caffeine for at least 12 hours prior to each MRI
•Subjects with a known contraindication to Adenosine and/or Regadenoson will only be enrolled in scans where no stress agent will be administered