Caffeine Consumption and Mortality in Diabetes: an Analysis of National Health and Nutrition Examination Survey (NHANES) 1999-2010
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 3,052
- 主要终点
- All-cause mortality
研究概览
简要总结
Previous studies suggested an inverse relationship between coffee consumption and mortality in the general population. Furthermore, an inverse association between coffee consumption and serum biomarkers of inflammation and insulin resistance has been described. Prospective studies showed that coffee consumption might be associated with reduction in the incidence of type 2 diabetes. Although caffeine consumption appears to be associated with a decreased risk of developing type 2 diabetes, the relationship between caffeine consumption and mortality in patients with diabetes remains uncertain. The current analysis aimed to assess the effects of caffeine consumption and caffeine source on all-cause, cardiovascular and cancer mortality among patients with diabetes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •NHANES participants from 1999 to 2010 above 18-year old, with diagnosis of diabetes
排除标准
- •Implausible alimentary reports (defined as consumption of less than 500 kcal/day or more than 3500 kcal/day)
- •Missing information on caffeine consumption
- •Missing information on mortality
结局指标
主要结局
All-cause mortality
时间窗: From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to 12 years
All-cause mortality as assessed by NHANES linked National Death Index public-access
次要结局
- Cardiovascular mortality(From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to 12 years)
- Cancer mortality(From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to 12 years)
研究者
João Sérgio Neves
MD
Universidade do Porto