Validation of SARS CoV-2 RT-PCR testing usingcombinatorial tapestry pooling of samples: a multi-centre study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 321
- 试验地点
- 5
- 主要终点
- The primary outcome is the sensitivity and specificity of combinatorial tapestry
研究概览
简要总结
COVID is caused by the SARS CoV2 virus. Currently, we are testing individuals for the presence of the virus using nasal swabs. The cost of this test and the shortage of testing kits limits the number of tests that can be performed.
It has been shown that pooling of samples from different individuals is a cost-effective way to test for the presence of virus. In this study, we plan to compare two methods of pooling samples. The study will be carried out on samples which have already been collected for individual testing and no additional samples will be collected from individuals. The results of the pooled testing will be compared with the results of the individual tests (which will be carried out as standard of care)
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 1.00 Day(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •samples of nasopharyngeal swabs submitted for COVID testing to each of the participating centres as per current testing guidelines.
排除标准
- 未提供
结局指标
主要结局
The primary outcome is the sensitivity and specificity of combinatorial tapestry
时间窗: baseline
pooling technique as compared to individual testing, across various prevalence rates and degrees of pooling.
时间窗: baseline
次要结局
- The sensitivity and specificity of the simple pooled technique as compared to individual technique,(across various prevalence rates and degrees of pooling)
- The sensitivity and specificity of each level of combinatorial tapestry pooling as compared to simple pooling at the same level.(baseline)
- Cost per individual for each of the three types of testing (for negative and positive tests) at different(levels of pooling)