DRKS00003480招募中4 期
eural Correlates of SSRI Drug Response: Impact of Stress System Genes
Abteilung für biologische PsychiatrieUniversitätsklink für Psychiatrie und Psychotherapie, Medizinische Universität WienAllgemeines Krankenhaus Wien0 个研究点目标入组 30 人开始时间: 2012年1月24日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- N/a: Single Arm Study
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 45 Years（—）
- 性别
- All
入选标准
- •willingness and competence to sign the informed consent form voluntarily
- •- aged 18 – 45 years
- •- right-handedness
- •- a DSM-IV diagnosis of a major depressive episode by a structured
- •clinical interview (SCID)
- •- a MADRS score =20 and = 30
- •- ability to be managed as outpatients
- •- ability to fulfill the criteria to undergo an MRI scan
- •- Caucasian subjects of European ancestry
排除标准
- •- previous or concurrent major medical or neurological illness
- •- clinically significant abnormal values in routine laboratory screening or general physical examination
- •- DSM-IV diagnosis of substance dependence within the past year or current substance abuse,
- •except for caffeine or nicotine
- •- DSM-IV diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder, or an anxiety disorder as a primary diagnosis
- •- the use of any psychotropic drug within the last two months
- •- unresponsiveness of a former major depressive episode to an adequate antidepressive drug dosing of at least 6 weeks duration or any kind of therapy resistance
- •- a history of severe drug allergy or hypersensitivity or known hypersensitivity to escitalopram
- •- being acutely suicidal either indicated by a score = 5 on item 10 (suicidal thoughts) on the MADRS or a score = 4 on the HAM-D 21 (suicidal thoughts) or according to the investigator´s opinion
- •- failures to comply with the study protocol or to follow the instructions of the investigating team
- •- current pregnancy or breast feeding
- •- metallic implants or other contraindications to MRI
研究者
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