Antibiotic treatment following surgical drainage of perianal abscess: a double-blind, placebo-controlled, randomized trial. - ATLAS trial

heelkunde0 个研究点目标入组 298 人开始时间: 待定最近更新: 2024年4月9日

适应症

试验速览

暂无简介。

•-a coexistent perianal fistula,
•-secondary or recurrent perianal abscess,
•-presence of an internal fistula opening,
•-any additional surgical procedure performed during the same session,
•-previous (peri)anal surgery,
•-inflammatory bowel disease,
•-history of radiation of the pelvic area,
•-anorectal malignancy,
•-immunodeficiency,
•-kidney failure, eGFR <30ml/min
•-valvular heart disease,
•-pregnancy or lactation,
•-antibiotic prophylaxis indicated for another reason,
•-immunosuppressive medication at the time of surgery,
•-allergy to metronidazole or ciprofloxacin,
•-not able or trouble with swallowing pills
•-concomitant use of:
•o Tizanidine, theophylline, clozapine, olanzapine, pirfenidone, carbamazepine,
•agomelatine (these are all CYP1A2 substrates, ciprofloxacin is an inhibitor)
•o Amiodarone, erythromycin, sotalol, azithromycin, citalopram, escitalopram,
•flecainide, fluconazole, haloperidol >5mg/day, methadone, ondansetron
•(concerning prolonged QT interval in combination with ciprofloxacin)
•o Lithium (can cause toxic levels with metronidazole)
•o Lopinavir/ritonavir, ritonavir capsules, temsirolimus, disulfiram (antabuse),
•mebendazole (can cause serious side effects, confusion and psychosis in
•combination with metronidazole)
•o Corticosteroids (in combination with ciprofloxacin higher risk of tendinitis
•and tendon rupture).

发起方

heelkunde