NCT03642223已完成不适用
Relation Btw Adiposity, Inflammation & Iron Absorption:Comparison Btw Central & Peripheral Adiposity
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 121
- 试验地点
- 1
- 主要终点
- Fractional and total iron absorption
研究概览
简要总结
Adiposity is a state of sub-clinical inflammation, thus hepcidin is increased in adiposity, often leading to iron deficiency in this population group. Central adiposity is generally considered having a greater negative effect on health compared to peripheral adiposity. Whether this can be also seen in hepcidin and thereby in iron absorption is uncertain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 55 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •either normal-weight (BMI 18-25kg/m2) or overweight/obese (BMI 28-50kg/m2) with either central or peripheral fat deposits based on DEXA
排除标准
- •Iron Supplement or antibiotic intake within 2 weeks before study start
- •diagnosed chronic disease or gastrointestinal disorders
- •regular use of medication (except contraceptives)
- •pregnancy
- •lactation
- •blood donation or surgery within the last 4 months.
研究组 & 干预措施
central adiposity
Experimental
干预措施: Stable iron isotopes (Other)
peripheral adiposity
Experimental
干预措施: Stable iron isotopes (Other)
normal-weight
Active Comparator
干预措施: Stable iron isotopes (Other)
结局指标
主要结局
Fractional and total iron absorption
时间窗: 14days after the administration of the test meal
次要结局
- Serum IL-6(at baseline)
- Serum AGP(at baseline)
- Serum Hepcidin(at baseline)
- Serum ferritin(at baseline)
- Serum TfR(at baseline)
- Serum CRP(at baseline)
研究者
Prof. Michael B. Zimmermann
Prof. Dr. med.
Swiss Federal Institute of Technology
研究点 (1)
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