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临床试验/NCT07299643
NCT07299643已完成不适用

The Application of 3DSlicer Technology in Percutaneous Nephrolithotomy Surgery.

Ting Huang1 个研究点 分布在 1 个国家目标入组 105 人开始时间: 2023年1月1日最近更新:

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
105
试验地点
1
主要终点
predict the stone free possibility of kidey stone

研究概览

简要总结

Objectives: Percutaneous nephrolithotomy (PCNL) has become a widely used technique for managing renal calculi. However, the rate of residual stones remains high. Accurate preoperative assessment of the individual's renal collecting system anatomy and strategic planning of access pathways are essential for improving stone-free outcomes. This study investigated whether characteristics of the target calyx can predict stone clearance through a distinct puncture calyx and developed a model to estimate the risk of residual stones in the target calyx.

Methods: We performed a retrospective analysis of patients who underwent PCNL in the urology department of our center between January 2023 and June 2025, in whom the puncture calyx differed from the target calyx (67 cases with complete stone clearance and 38 cases with residual stones). Three-dimensional reconstructions of the renal collecting system and calculi were generated from preoperative urinary tract CT scans, and spatial parameters were obtained from these models. Patient and stone characteristics were combined with 3D-derived variables for binary logistic regression to identify predictive factors and construct nomograms. Model performance was assessed using receiver operating characteristic (ROC) and calibration curves, while clinical utility was evaluated through decision curve analysis (DCA). The Youden index was applied to determine the optimal cutoff value.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Retrospective

入排标准

年龄范围
28 Years 至 77 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • ① preoperative diagnosis of renal calculi confirmed by computed tomography urography (CTU); ② completion of standard-channel (F24) PCNL with the puncture and target calyces situated in different renal calyces; and ③ postoperative CT imaging performed within one week after surgery.

排除标准

  • ① anatomical abnormalities of the affected kidney, such as severe renal rotation or horseshoe kidney; and ② history of secondary procedures, including repeat PCNL or renal puncture with fistula formation.

结局指标

主要结局

predict the stone free possibility of kidey stone

时间窗: 2023-2025

DCA curve

次要结局

未报告次要终点

研究者

发起方
Ting Huang
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Ting Huang

Principal Investigator

Zhejiang University

研究点 (1)

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