Bio-psycho-social Pathways Underlying the Effects of Qigong Among Comorbid Depressed Elderly With Chronic Conditions
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- Patient Health Questionnaire (PHQ)
研究概览
简要总结
Depression and chronic medical conditions are common in older adults. Qigong is increasingly documented to have anti-depressive effects for older adults. Nevertheless, the scientific concepts behind qigong remain a mystery. To fill the knowledge gap, the neurobiological mechanism of the effects of qigong was explored. In addition, the benefits of qigong on subjective well-being, functional independence, sleep quality, mobility, and muscle strength were also tested. After random assignment, intervention group (n = 14) went through individual qigong exercise twice a week and for 12 weeks,whereas control group (n = 16) was involved in cognitive training activities with mobilization elements. The psychosocial, physical, and neurobiological outcomes of the two groups were compared.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aged 60 or above
- •have been suffering from chronic medical conditions for more than one year
- •have depressive symptoms as indicated by Geriatric Depression Scale (GDS ≥ 6)
排除标准
- •have practiced or received training of any form of mind-body exercises (including tai chi, yoga, and qigong) during the 6 months prior to intervention.
- •have changed medication or the dosage prior to or during intervention
- •have obvious cognitive and language impairment or score less than 20 in Mini-Mental State Examination (MMSE)
- •undergo electroconvulsive therapy, psychotherapy, or psychoeducation
- •cannot demonstrate satisfactory sitting balance
研究组 & 干预措施
Qigong Training
干预措施: Qigong Training (Behavioral)
Cognitive Training
干预措施: Cognitive Training (Behavioral)
结局指标
主要结局
Patient Health Questionnaire (PHQ)
时间窗: the change from baseline to the completion of intervention (12 weeks later)
Patient Health Questionnaire (PHQ) is used to assess the experience of depressive symptoms. The frequency of each symptom was indicated based on a 4-point scale (0 = never; 3 = almost every day). A total score ranged from 0 to 27 can be derived, with higher score indicating severer depressive symptoms.
次要结局
- Brain Deprived Neurotrophic Factor (BDNF) Level(baseline and 12 weeks after baseline)
- Depression Anxiety Stress Scale (DASS-21)(baseline, 12 weeks after baseline, and 16 weeks after baseline)
- Personal Well-Being Index (PWI)(baseline, 12 weeks after baseline, and 16 weeks after baseline)
- Functional Independence Measure (FIM)(baseline, 12 weeks after baseline, and 16 weeks after baseline)
- Timed up and Go Test (TUG)(baseline, 12 weeks after baseline, and 16 weeks after baseline)
- Handgrip Strength(baseline, 12 weeks after baseline, and 16 weeks after baseline)
- Salivary Cortisol Level(baseline and 12 weeks after baseline)
- Serotonin 5-HT Level(baseline and 12 weeks after baseline)
- Pittsburgh Sleep Quality Index (PSQI)(baseline, 12 weeks after baseline, and 16 weeks after baseline)
研究者
TSANG Hector Wing-Hong
Professor and Head of Department of Rehabilitation Sciences
The Hong Kong Polytechnic University