Objective Markers of Pain Perception in Humans: a Study in Healthy Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 4
- 主要终点
- EEG Gamma power.
研究概览
简要总结
Determine objective markers of pain perception remains a major scientific and medical issue. Various tools have been proposed to objectify pain, but their adaptability to different clinical contexts are limited. Our working hypothesis considers that the research for markers of immediate pain perception should be based on an electrophysiological approach, based on the combined analysis of EEG and autonomic responses.
详细描述
This project aims to study the cortical and autonomic responses induced by tonic painful stimulation compared to those induced by comparable sensory and stressful stimulations, by combining high density EEG, cutaneous sympathetic, cardiovascular and pupillary recordings.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Affiliate or beneficiary of social security
- •Signature of consent
排除标准
- •History of cardiovascular disease (vagal syncope, hypertension, etc ...), renal, metabolic (diabetes ...), psychiatric (depression, etc ...) or neurological (seizure, etc ...) syndromes;
- •Reynaud's syndrome;
- •Raynaud's disease;
- •Acrocyanosis;
- •Known rhythm disorders;
- •Participation at the same time in another clinical trial;
- •Taking a medical treatment;
- •Suffering from acute (complaint of pain in the week before the test) or chronic pain,
- •Allergic to conductive gel for electrodes.
研究组 & 干预措施
EEG responses
The study compares electroencephalographical responses (EEG) to painful stimuli tonic to those evoked by non-painful stimuli and with or without virtual reality
干预措施: Painful tonic stimuli (Other)
EEG responses
The study compares electroencephalographical responses (EEG) to painful stimuli tonic to those evoked by non-painful stimuli and with or without virtual reality
干预措施: non-painful stimuli (Other)
结局指标
主要结局
EEG Gamma power.
时间窗: Baseline
The EGG signals are compared between a painful stimuli tonic to those evoked by non-painful stimuli.
次要结局
- Magnitude of the sympathetic cutaneous reactivity(Baseline)
- Amplitude of pupillary dilation(Baseline)
- ratio of low to high frequency spectral powers(Baseline)