JPRN-jRCTs031210314
Recruiting
N/A
Biomarker development study of pain quantification in patients with chronic pain using AMPA receptor density as an index
Miyazaki Tomoyuki0 sites60 target enrollmentSeptember 15, 2021
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Chronic pain
- Sponsor
- Miyazaki Tomoyuki
- Enrollment
- 60
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients that meet all of the following criteria 1\) to 4\).
- •1\) Patients having sustained pain that lasts for 3 months or longer
- •2\) Patients who meet any of each following (1\) to (3\) without any overlap with each other
- •(1\) Patients having postoperative pain that was developed after surgery: Patients must meet the following (A) and (B)
- •(A) Pain that is observed around surgical sites and developed after surgery
- •(B) Pain that onset was within 3 months after surgery
- •(2\) Patients having pain caused by psychosocial factors: Patients must meet each criterion (A) or (B) and also meet the conditions of (C) and (D).
- •(A) Pain that followed Neurotic symptoms (psychiatric symptoms) such as anxiety and depressive symptoms
- •(B) Those corresponding to F45\.4 Persistent somatic symptom pain disorder in ICD\-10 or Physical symptom pain is the main symptom in DSM\-5
- •(C) Does not meet the following diagnostic criteria;
Exclusion Criteria
- •1\) Implantation of metal substances and pacemakers
- •2\) head, neck and body size not suitable for MRI scanner
- •3\) A tattoo larger than one point (including tattoo and art makeup)
- •4\) Advanced claustrophobic
- •5\) A remarkable variant of brain structure (including congenital and traumatic)
- •6\) Patient with renal dysfunction (Serum creatinine 1\.5 mg / dl or more)
- •7\) Patient with liver dysfunction (AST 150 IU / L or more ALT 150 IU / L or more)
- •8\) Combination of serious neurologic diseases (neurodegenerative diseases, cases of cerebral hemorrhage and cerebral infarction which are not slight in the image before this study participation)
- •9\) Sensitive to alcohol
- •10\) Participating in unapproved nuclear medicine clinical trials and clinical trials within 6 months prior to enrollment
Outcomes
Primary Outcomes
Not specified
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