Development and Validation of a Real-time Prediction Model for Acute Kidney Injury in Hospitalized Patients
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 161,876
- 主要终点
- Predictive performance of the prediction model for Acute Kidney Injury
研究概览
简要总结
Early prediction of acute kidney injury (AKI) may provide a crucial opportunity for AKI prevention. To date, no prediction model targeting AKI among general hospitalized patients in developing countries has been published. We developed a simple, real-time, interpretable AKI prediction model for general hospitalized patients from a large tertiary hospital in China, and validated it across five independent, geographically distinct, different tiered hospitals.
详细描述
Early prediction of acute kidney injury (AKI) may provide a crucial opportunity for AKI prevention. To date, no prediction model targeting AKI among general hospitalized patients in developing countries has been published. We developed a simple, real-time, interpretable AKI prediction model for general hospitalized patients from a large tertiary hospital in China using the machine learning technique, and then validated the performance of the prediction model across five independent, geographically distinct, different tiered hospitals in China.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (18 years and older) admitted to five hospitals during the study period
排除标准
- •Have less than 2 documented serum creatinine (Scr) measurements during hospitalization
- •Being diagnosed with end-stage renal disease (ESRD)
- •Maintained on dialysis or had an initial Scr greater than or equal to 4.0 mg/dL at admission
- •Developed AKI prior to admission or within 24 hours after admission
- •Length of stay shorter than 24 hours
- •Underwent kidney transplantation or nephrectomy during hospitalization
- •With all Scr measurements lower than or equal to 0.6 mg/dL from 90 days prior to admission until discharge.
结局指标
主要结局
Predictive performance of the prediction model for Acute Kidney Injury
时间窗: through study completion, varied from one to three years in different validation cohorts.
Evaluated using AUC
次要结局
未报告次要终点