Postprandial Inflammatory and Metabolic Responses Induced by the Authentic Ladotyri Mytilinis PDO Cheese and Italian Parmesan PDO Cheese
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Changes from baseline of Total Antioxidant Capacity at 30 minutes, 1.5 hours and 3 hours
研究概览
简要总结
The purpose of this study was the investigation of the postprandial metabolic responses, after the intake of a traditional, Ladotyri Mytilinis cheese, compared to corresponding responses after an Italian Parmesan cheese consumption, in healthy participants.
详细描述
A pilot cross-over, randomized and single-blinded, intervention-clinical trial was conducted, in ten healthy men and women subjects, aged eighteen to thirty years, after random allocation into the control and the intervention group, received a high-fat and carbohydrates meal, containing Ladotyri Mytilinis (the authentic nonrefrigerated recipe) or Italian Parmesan, PDO cheeses. After a washout week, participants consumed the same meals, conversely. Differences on postprandial responses of serum total, High Density Lipoprotein (HDL-), Low Density Lipoprotein (LDL-) cholesterol, glucose, triglycerides and uric acid levels, as well as of plasma total antioxidant capacity according to Ferric Reducing Antioxidant Power method, were determined between groups in fasting, thirty minutes, one and a half hour, and three hours after meal intake.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Single (Participant)
盲法说明
Only investigator knew the type of meal, consumed by each participant
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-65 years
- •Willingness to join and complete the nutritional intervention
排除标准
- •Inability or unwillingness to provide informed consent
- •Three-month nutritional supplement
- •Age over 65 years or below 18 years
- •Chronic diseases history
- •Hemoglobin A1c - HbA1c > 5.7 %
- •Abnormal Body Mass Index (BMI) (> 25 kg / m2)
- •Abnormal hematological or biochemical profile (total cholesterol > 240 mg/dL, triglycerides > 250 mg/dL, glucose > 100 mg/dL)
- •Alcohol overdose (> 40 g alcohol / day)
- •Heavy smoking (> 10 cigarettes / day)
- •Concurrent participation in another intervention study or unconsciousness in previous blood draws
结局指标
主要结局
Changes from baseline of Total Antioxidant Capacity at 30 minutes, 1.5 hours and 3 hours
时间窗: 3 hours
Plasma antioxidant activity
次要结局
- Changes from baseline of total Cholesterol at 30 minutes, 1.5 hours and 3 hours(3 hours)
- Changes from baseline of Uric Acid at 30 minutes, 1.5 hours and 3 hours(3 hours)
- Changes from baseline of High Density Lipoprotein cholesterol (HDL-) at 30 minutes, 1.5 hours and 3 hours(3 hours)
- Changes from baseline of Low Density Lipoprotein cholesterol (LDL-) at 30 minutes, 1.5 hours and 3 hours(3 hours)
- Changes from baseline of triglycerides at 30 minutes, 1.5 hours and 3 hours(3 hours)
- Changes from baseline of glucose at 30 minutes, 1.5 hours and 3 hours(3 hours)
研究者
ANTONIOS KOUTELIDAKIS
Professor Antonios E. Koutelidakis
University of the Aegean