NCT05865977招募中不适用
Diaphragmatic Tissue Doppler Imaging During a Spontaneous Breathing Trial to Predict Extubation Failure in Preterm Infants
Wang Jianhui1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2023年2月25日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Change in diaphragmatic displacement velocity
研究概览
简要总结
Weaning from mechanical ventilation is a critical issue and the diaphragmatic disfunction has been demonstrated to play an important role in extubation failure. the aim of present investigation is to evaluate diaphragmatic excursion velocity during in patients undergoing spontaneous breathing trial through tissue Doppler analysis in both inspiration and expiration.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Days 至 6 Months（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •premature infants with gestational age <32 weeks and supported by invasive mechanical ventilation ≥48 hours
- •All the indications for extubation are met：cough or vomiting due to spontaneous breathing and sputum aspiration; ventilator parameters in recent 24 hours: MAP < 8cmH2O, RR < 30 times/min, FiO2 < 30%; Arterial blood gas: pH > 7.25, (PaCO2< 60mmHg, BE < 8mmol/L, oxygen saturation > 90%
- •a successful SBT
- •parents or legal guardians sign informed consent to attend this study
排除标准
- •accidental extubation
- •chest CT or bronchoscopy during hospitalization indicated congenital airway dysplasia
- •complex congenital heart disease
- •congenital metabolic diseases, neuromuscular diseases
- •severe brain injury
- •surgical mechanical ventilation
- •give up before extubation;
- •pneumothorax or pleural effusion
- •no consent is signed
结局指标
主要结局
Change in diaphragmatic displacement velocity
时间窗: an average of 20 minutes
Inspiratory and expiratory diaphragmatic displacement velocity evaluated with tissue doppler during the assisted ventilation modality which preceded the trial, during the spontaneous breathing trial and in spontaneous breathing.
次要结局
- Number of patients who experienced weaning failure(48 hours)
- Silverman Andersen Respiratory Severity Score (SA-RSS)(an average of 20 min)
- Gas exchange - arterial carbon dioxide tension(through each trial completion, an average of 20 minutes)
- Gas exchange - pH(an average of 20 minutes)
- Gas exchange - arterial oxygen tension(an average of 20 min)
- Diaphragmatic acceleration and deceleration(an average of 20 minutes)
研究者
Wang Jianhui
Attending doctor
Children's Hospital of Chongqing Medical University
研究点 (1)
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