NCT02272556已完成不适用
Investigating the Role of Polyol Pathway in the Central Nervous System
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 138
- 试验地点
- 2
- 主要终点
- Metabolite Measurements by MRS
研究概览
简要总结
Patients will undergo magnetic resonance spectroscopy (MRS) scanning to noninvasively measure intracerebral and plasma metabolite levels at baseline and following 2 and 4 hours of hyperglycemia. Subjects will also undergo a lumbar puncture at a separate occasion to assess cerebrospinal fluid levels of metabolites.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Type 2 DM with HbA1C treated with metformin, sulfonylurea, insulin, or combination OR age-matched, non-diabetic obese (BMI > 30 kg/m^2) OR age-matched lean, healthy control subjects (BMI < 25 kg/m^2)
- •Age 18-55
- •BMI 18-45 kg/m^2
排除标准
- •Creatinine > 1.5 mg/dL
- •Hgb < 10 mg/dL
- •ALT > 2.5 x ULN
- •Untreated thyroid disease
- •Uncontrolled Hypertension
- •Known Neurological Disorders
- •Untreated Psychiatric Disorders
- •Malignancy
- •Bleeding Disorders
- •Current or recent steroid use in last 3 months
- •Illicit drug use
- •Pregnancy, actively seeking pregnancy, or breastfeeding
- •Inability to enter MRI/MRS
结局指标
主要结局
Metabolite Measurements by MRS
时间窗: 4 hours post hyperglycemia
metabolite levels will be measured by MRS
次要结局
- Satiety Ratings(4 hours post hyperglycemia)
- Hunger Ratings(4 hours post hyperglycemia)
- Cognitive State(4 hours post hyperglycemia)
研究者
研究点 (2)
Loading locations...
相似试验
已完成
不适用
MRS to Determine Neuroinflammation and Oxidative Stress in MPS IMucopolysaccharidosis Type INCT03576729University of Minnesota30
招募中
不适用
Magnetic Resonance Elastography in Patients With Abdominal Aortic AneurysmsAbdominal Aortic AneurysmNCT02387255Ohio State University165
已完成
不适用
Magnetic Resonance Spectroscopy Imaging in Predicting Response to Vorinostat and Temozolomide in Patients With Recurrent or Progressive GlioblastomaAdult GlioblastomaRecurrent Adult Brain TumorDepressionNCT01342757National Cancer Institute (NCI)12
招募中
不适用
Magnetic Resonance Imaging and Biomarkers for Muscular DystrophyBecker Muscular DystrophyDuchenne Muscular DystrophyNCT01484678University of Florida550
进行中（未招募）
不适用
An Imaging-based Quantitative Biomarker Assay for NAFLD in ChildrenNAFLDNASHNCT06354491University of Wisconsin, Madison24