Effects of Smoking on Non-surgical Periodontal Therapy in Generalized Aggressive Periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 27
- 主要终点
- Change in Clinical Attachment Level (CAL)
研究概览
简要总结
Smoking is the major preventable risk factor in the initiation and progression of periodontal diseases. Periodontitis risk was found to be 3.9 times higher among smokers aged between 19-30 years and 2.8 times higher among smokers aged 31-40 years compared to non-smokers. Aggressive periodontitis (AgP), is characterized by a rapid attachment loss usually incompatible with the amount of plaque and dental calculus. It is often not possible to predict the prognosis of treatment with various treatment options in cases of aggressive periodontitis. It was hypothesized that non-smoker patients with generalized aggressive periodontitis (GAgP) will respond better to conventional mechanical non-surgical periodontal therapy compared to the smokers. Therefore, the aim of this study was to evaluate the effects of smoking on the outcomes of non-surgical periodontal treatment in terms of the clinical, biochemical and microbiological parameters.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Having at least six permanent teeth, including incisors and/or first molars with severe periodontal disease
- •Having at least one site with probing depth (PD) and clinical attachment level (CAL) ≥5 mm and six teeth other than first molars and incisors with similar PD and CAL measurements
- •Familial aggregation
排除标准
- •Medical disorders such as diabetes mellitus, immunological disorders
- •Having an antibiotic or periodontal treatment in the last 6 months
- •Having <15 teeth
结局指标
主要结局
Change in Clinical Attachment Level (CAL)
时间窗: Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy
次要结局
- Change in Probing Depth (PD)(Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy)
- Change in Plaque Index (PI)(Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy)
- Change in Bleeding on Probing (BoP)(Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy)
- Changing of the amount of pathogen microorganisms(Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy)
- Changing of the salivary biomarkers(Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy)
- Changing of the serum biomarkers(Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy)
- Changing of the gingival crevicular fluid (GCF) biomarkers(Baseline and 1 month, 3 month, 6 month after non-surgical periodontal therapy)
研究者
Nurcan Buduneli
Clinical Professor
Ege University