Analysis of the Pre- and Post-prandial Levels of Appetite Regulatory Hormones in Adult Individuals
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- plasma leptin concentration
研究概览
简要总结
The present study aims to evaluate in adults with normal weight and with overweight or obesity who live in the city of La Plata the circulating levels of various hormones that regulate appetite and the gene expression of their receptors in peripheral blood mononuclear cells before and after food intake.
详细描述
the investigators plan a single test meal study in males and females with normal weight (NW) or overweight/obesity (OW/OB) assessing whether plasma appetite regulatory hormones levels are associated with different metabolic and anthropometric variables as well as with appetite sensations.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •adult individuals body mass index> 18.5 kg∙m-2
排除标准
- •chronic medical illness, personal history of diabetes, history of medical condition, or medication related to obesity or diabetes risk status.
研究组 & 干预措施
food intake (breakfast)
the breakfast composition is 56 kcal% carbohydrates, 12 kcal% protein and 34 kcal% lipids and comprises yogurt, cereals and almonds
干预措施: food (breakfast) (Dietary Supplement)
结局指标
主要结局
plasma leptin concentration
时间窗: 1 hour post -prandial
leptin concentration (ug/ml)
plasma glucagon-like peptide 1 concentration
时间窗: 1 hour post -prandial
glucagon-like peptide 1 concentration (ug/ml)
plasma ghrelin concentration
时间窗: 1 hour post -prandial
ghrelin concentration (fmol/ml)
plasma des-acyl ghrelin concentration
时间窗: 1 hour post -prandial
des-acyl ghrelin concentration (fmol/ml)
ghrelin deacylation
时间窗: 1 hour post -prandial
plasma desacylase actvitity of ghrelin (relative units)
hunger sensation
时间窗: pre-prandial and 15, 30, 45 and 60 min post-prandial
visual analog scale (cm)
plasma liver antimicrobial peptide 2 concentration
时间窗: 1 hour post -prandial
liver antimicrobial peptide 2 concentration (pmol/ml)
plasma glucose concentration
时间窗: 1 hour post -prandial
glucose concentration (mg%)
insulin receptor gene expression in peripheral blood mononuclear cells
时间窗: pre-prandial
insulin receptor gene expression in peripheral blood mononuclear cells (relative expression)
"prospective food consumption" sensation
时间窗: pre-prandial and 15, 30, 45 and 60 min post-prandial
visual analog scale (cm)
plasma triglycerides concentration
时间窗: 1 hour post -prandial
triglycerides concentration (mg%)
leptin receptor gene expression in peripheral blood mononuclear cells
时间窗: pre-prandial
leptin receptor gene expression in peripheral blood mononuclear cells (relative expression)
ghrelin receptor gene expression in peripheral blood mononuclear cells
时间窗: pre-prandial
ghrelin receptor gene expression in peripheral blood mononuclear cells (relative expression)
plasma total cholesterol concentration
时间窗: 1 hour post -prandial
total cholesterol concentration (mg%)
ghrelin proteolysis
时间窗: 1 hour post -prandial
plasma proteolytic activity of ghrelin (relative units)
fullness sensation
时间窗: pre-prandial and 15, 30, 45 and 60 min post-prandial
visual analog scale (cm)
"desire to eat" sensation
时间窗: pre-prandial and 15, 30, 45 and 60 min post-prandial
visual analog scale (cm)
plasma ghrelin concentration
时间窗: pre -prandial
ghrelin concentration (fmol/ml)
plasma leptin concentration
时间窗: pre -prandial
leptin concentration (ug/ml)
plasma glucagon-like peptide 1 concentration
时间窗: pre -prandial
glucagon-like peptide 1 concentration (ug/ml)
plasma liver antimicrobial peptide 2 concentration
时间窗: pre -prandial
liver antimicrobial peptide 2 concentration (pmol/ml)
plasma des-acyl ghrelin concentration
时间窗: pre -prandial
des-acyl ghrelin concentration (fmol/ml)
plasma glucose concentration
时间窗: pre -prandial
glucose concentration (mg%)
plasma triglycerides concentration
时间窗: pre-prandial
triglycerides concentration (mg%)
plasma total cholesterol concentration
时间窗: pre -prandial
total cholesterol concentration (mg%)
ghrelin proteolysis
时间窗: pre -prandial
plasma proteolytic activity of ghrelin (relative units)
ghrelin deacylation
时间窗: pre -prandial
plasma desacylase actvitity of ghrelin (relative units)
次要结局
未报告次要终点