A Randomised Controlled Trial in older adults with mild cognitive or memory impairment, investigating the Cognitive Benefits of a Combined Flavonoid/Fatty Acid Intervention and Underlying Mechanisms of Action: The COGNITIVE AGING NUTRITION and NEUROGENESIS (CANN) Trial

Swinburne Univeristy0 个研究点目标入组 240 人开始时间: 2015年10月7日最近更新: 2020年1月13日

适应症

试验速览

暂无简介。

•For main study:
•Male and female, aged 55 years and over
•Mild cognitive impairment (MCI) or subjective memory impairment (SMI) with no indication of clinical dementia or depression
•Willing and able to provide written informed consent.
•Understands and is willing and able to comply with all study procedures.
•Fluent in written and spoken English.
•In good general health including blood biochemical, haematological and urinalysis within the normal range at
•screening (as judged by the clinical advisor)
•Normal, or corrected to normal vision and hearing
•Right handed, for MRI
•Stable use of any prescribed medication for at least four weeks
•For healthy controls sub-study:
•The same inclusion criteria apply except that participants must not have MCI or SMI

•Diagnosis of Alzheimer's disease (AD) or other form of dementia or significant neurological disorder
•Parent or sibling who developed premature dementia <60y (suggestive of a familial monogenic form of cognitive decline)
•Past history or MRI evidence of brain damage including significant trauma, stroke, learning difficulties or serious neurological disorder, including loss of consciousness > 24 hours
•History of alcohol or drug dependency within the last 2 years
•Other clinically diagnosed psychiatric disorder likely to affect the cognitive measures (as judged by clinical adviser)
•Existing diagnosed gastrointestinal disorders likely to impact on absorption of flavonoids and fatty acids (as judged by clinical adviser)
•Major cardiovascular event, e.g. myocardial infarction or stroke, in the last 12 months
•Carotid stents or severe stenosis
•Known allergy to fish or any other component in the intervention supplements
•Existing medical conditions likely to affect the study measures (as judged by clinical adviser)
•Uncontrolled hypertension (Systolic Blood Pressure (SBP) >140mmHg, Diastolic Blood Pressure (DBP) >90mmHg)
•BMI >40kg/m2

发起方

Swinburne Univeristy