Autonomic Dysfunction in Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis : A Comparative Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 主要终点
- Prevalence of autonomic dysfunction in Neuromyelitis Optica Spectrum Disorder
研究概览
简要总结
To compare the frequency and patterns of autonomic dysfunction in patients with NMOSD and MS, and to investigate its correlations with clinical disability, radiological findings, fatigue, and quality of life parameters
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (≥18 years , both sexes.
- •Confirmed diagnosis of NMOSD according to the 2015 International Consensus Criteria.
- •Confirmed diagnosis of RRMS according to the 2024 McDonald diagnostic criteria.
排除标准
- •Comorbidities affecting autonomic function (e.g., diabetes, Parkinsonism).
- •Medications known to interfere with autonomic testing.
- •Cognitive impairment precluding questionnaire completion.
结局指标
主要结局
Prevalence of autonomic dysfunction in Neuromyelitis Optica Spectrum Disorder
时间窗: Baseline
Autonomic dysfunction assessment using COMPASS-31 questionnaire (Arabic validated version) (12):The Composite Autonomic Symptom Score 31 (COMPASS-31) is a validated, self-administered questionnaire derived from the original 169-item Autonomic Symptom Profile. It provides a concise yet comprehensive evaluation of autonomic symptoms across six domains: orthostatic intolerance, vasomotor, secretomotor, gastrointestinal, bladder, and pupillomotor functions. The total weighted score ranges from 0-100, with higher scores reflecting greater autonomic symptom burden.
次要结局
- Correlations with disability, MRI findings, fatigue, and quality of life.(baseline)
研究者
Mohamed Moshref abd alsattar
Resident doctor at neurology and psychiatry department
Assiut University