Neural Adaptations to Metronome-Paced Strength Training: Insights From Neuroscience and Human Movement Variability
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Maximal Compound Action Potentials (Mmax) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups
研究概览
简要总结
The aim of the study is to investigate the effects of incorporating variability within Resistance Training (RT) methods on the neural adaptations along the corticospinal tract and on neuromuscular function. The literature suggests that RTis one of the most common modalities to enhance and restore muscle function and its practice results in adaptation in neural and morphological adaptations. It is also known that conditions such as ageing and injury have a negative impact on neural drive to the muscles with consequences at motor control level that are not addressed by traditional RT. Recent approaches such as metronome paced strength training have been used to cover this motor control dimension through a greater control and consciousness of movement. However, this methodology tends not to incorporate the inherent variability and complex, fractal-like fluctuations that characterize human movement. The investigators propose that incorporating variability through a fractal-like metronome approach will speed up the neural adaptations which will be useful in injury rehab.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •aged between 18 and 40 years
排除标准
- •Neurologic conditions;
- •Lower limb disabilities or disease;
- •Not able to provide informed consent;
- •Have an implanted device (e.g. pacemakers) or any metal in the body;
- •Medication advised against the application of Transcranial Magnetic Stimulation;
- •History/family history of seizures, brain lesions or head trauma, neurological or psychiatric diseases, epilepsy, migraine
研究组 & 干预措施
Fractal Paced
Strength training in single leg extension machine, synchronizing each repetition with a fractal-like visual metronome, i.e., a metronome presenting visual external cues with variability within its temporal structure.
干预措施: Fractal Paced (Other)
Isochronous Paced
Strength training in single leg extension machine, synchronizing each repetition with a isochronus visual metronome, i.e., a metronome presenting visual external cues withthe same pace in each repetition (without variability)
干预措施: Isochronous Paced (Other)
Self Paced
Strength training in single leg extension machine at participants self pace.
干预措施: Self Paced (Other)
结局指标
主要结局
Maximal Compound Action Potentials (Mmax) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups
时间窗: PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)
Mmax is a measure assessed through peripheral nerve stimulation and represents the maximal capacity of recruit the motoneurons that innerve a muscle.
StartReact Gain changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups
时间窗: PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)
StartReact gain is a measure that is calculated following the StartReact protocol. It consists in measuring the participants' reaction times in response to visual stimuli (visual reaction time \[VRT\]), visual stimuli combined with a quiet sound (visual auditory reaction time \[VART\]) and visual startling stimuli (visual startling reaction time \[VSRT\]) and, then, apply the following formula: StartReact gain = (\[VRT - VSRT\]/\[VRT - VART\]).
Corticospinal Silent Period (CSP) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups
时间窗: PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)
CSP is a parameter extracted through the application of Transcranial Magnetic Stimulation (TMS). This parameter provides information regarding the level of inhibition along the corticospinal tract.
Intracortical Facilitation (ICF) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups
时间窗: PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)
ICF is a parameter extracted through the application of Transcranial Magnetic Stimulation (TMS). This parameter provides information regarding the level of facilitation within the motor cortex.
Lumbar Evoked Potentials (LEP) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups
时间窗: PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)
LEP is a measure extracted through the aplication of Lumbar stimulation. This measure allow to distinguish the adaptations that occur at spinal level as a result of strength training.
Corticospinal Excitability (CSE) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups
时间窗: PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)
CSE is a parameter extracted through the application of Transcranial Magnetic Stimulation (TMS). This parameter provides information regarding the level of excitability of the corticospinal tract.
Short-interval Intracortical Inhibition (SICI) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups
时间窗: PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention)
SICI is a parameter extracted through the application of Transcranial Magnetic Stimulation (TMS). This parameter provides information regarding the level of inhibition within the motor cortex.
次要结局
- Maximal Voluntary Isometric Contraction (MVIC) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups(PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention))
- Coefficient ov variation (CV) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups(PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention))
- Motor Unit Action Potentials (MUAP) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups(PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention))
- Single leg extension 1RM changes after 4-weeks intervention (PRE to POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups(PRE (baseline), POST (week 4), FUP (follow-up 4 weeks after the end of intervention))
- Sample Entropy (SampEn) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups(PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention))
- Firing Rate (FR) changes across the 4-weeks intervention (PRE to Week1, Week 2, Week 3, POST and follow-up) both within and between Fractal paced, Isochronus Paced and Self paced groups(PRE (baseline), W1 (week 1), W2 (week 2), W3 (week 3), POST (week 4), FUP (follow-up 4 weeks after the end of intervention))