ACTRN12623000361606尚未招募Unknown
The effect of hypochlorous acid spray on ocular symptoms and eyelid microbiota after 4 weeks of twice daily use in adults with and without dry eyes
SW Sydney0 个研究点目标入组 44 人开始时间: 2023年4月12日最近更新:
适应症
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
- 发起方
- 入组人数
- 44
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomised trial
- 主要目的
- Treatment
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 18 Years 至 o limit（—）
- 性别
- All
入选标准
- •Adults aged 18 years or older.
- •Able to read and comprehend English and provide informed consent by signing a record of informed consent.
- •Habitual visual acuity of at least 6/9 in each eye
- •Willingness to use hypochlorous acid spray on their eyelids twice daily for 4 weeks.
- •Willingness to attend two clinic visits at the School of Optometry and Vision Science
- •Willingness to not use any ocular lubricants and warm compresses for the duration of the study.
- •Willingness to not use eyelid cosmetics at the two visits.
排除标准
- •Known allergy to hypochlorous acid (All participants will be using 0.02% hypochlorous acid on their eyelids)
- •Comorbid ocular surface disease other than dry eye e.g., microbial conjunctivitis, microbial keratitis (Comorbid ocular surface disease states may contribute to ocular signs and symptoms that may confound result findings)
- •Ocular surgery or trauma in the last 6 months (Ocular surgery or trauma can introduce bacteria that may confound study results. Hypochlorous acid may affect the bacterial balance of eyes recovering from ocular surgery or trauma)
- •Use of contact lenses in the last 4 weeks. (Contact lens use can introduce other bacteria which may confound study results)
- •Current use of ocular or systemic medications that may affect ocular microbiota, including antibiotics, immunosuppressants, and steroids. (Some medications may alter tear film physiology which may confound study findings)
- •Current use of lid hygiene products such as lid wipes, lid foams and lid sprays with the exception of standard make-up remover that does not contain tea tree oil. (Concurrent use of lid cleaning products would alter normal presence of bacteria and confound the study findings)
- •Autoimmune disease or immunosuppressive conditions such as eczema, and psoriasis. (Hypochlorous acid may have potential side effects in people with autoimmune disease due to its effect on bacteria)
- •Lactating or pregnant women (The effect of hypochlorous acid on lactating and pregnant women and the foetus are unknown)
- •History of migraine or epilepsy exacerbated by flashing lights (exposure to flashing lights during LipiView examination may trigger an episode or attack)
研究者
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