NCT06809868招募中不适用
Role of Transposable Elements in Septic Immune Aging
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 116
- 试验地点
- 1
- 主要终点
- Immune Aging
研究概览
简要总结
The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is:
- Do transposable elements prematurely age the immune systems of patients with sepsis?
- Do transposable elements correlate with increased mortality in patients with sepsis in the ICU?
- Do transposable elements correlate with increased amount of secondary infections in patients with sepsis in the ICU?
Participants will have blood drawn from them but will not be subjected to additional interventions.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18 or older
- •Admitted to ICU with sepsis (Sepsis 3 Criteria)
- •SOFA score of at least 2 at time of enrollment
排除标准
- •Patients on organ transplantation immunosuppression
- •Patients with preexisting leukopenia
- •Cancer patients receiving CAR-T therapy
- •Patients who are under 18 years of age or otherwise deemed pediatric
- •Patients with an ongoing bleeding diathesis (ie: DIC, hemorrhagic shock)
- •Patients with a chronic hemoglobin below 7.0
- •Patients who, prior to their ICU admission, are blood transfusion dependent
研究组 & 干预措施
Healthy Individual Controls
Healthy individuals not admitted to the hospital.
干预措施: RNA and DNA Sequencing (Genetic)
Patients with Sepsis
Adult patients (age 18 and older) admitted to the intensive care unit (ICU) meeting Sepsis 3 Criteria.
干预措施: RNA and DNA Sequencing (Genetic)
结局指标
主要结局
Immune Aging
时间窗: 6 weeks
次要结局
- Mortality (30-day)(30 days)
- Secondary Infection(30 days)
研究者
研究点 (1)
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